Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1982-02-05
1984-10-16
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4351723, 435256, 435317, 935 28, 935 29, 935 69, 935 73, C12N 120, C12N 1500, C12N 118, C12N 100
Patent
active
044775717
ABSTRACT:
Chimeric plasmids capable of transforming bacteria and yeast are described. The plasmids carry the Cm (chloramphenicol resistance) gene and the Tc (tetracycline resistance) gene as selectable markers. The Cm gene allows the plasmids to be selected for in wild-type strains of the yeast Saccharomyces cerevisiae. The Tc gene allows heterologous genes cloned into the plasmids to be selected for in Escherichia coli bacteria.
REFERENCES:
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Cohen, J., Eccleshall, T., Needleman, R., Federoff, H., Buchferer, B., & Marmur, J. "Functional Expression in Yeast of the Escherichia coli Plasmid Gene Coding for Chloramphenicol Acetyltransferase" Proc. Natl. Acad. Sci. 77: 1078-1082 (1980).
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Stinchcomb, D., Struhl, K., & Davis, R. "Isolation and Characterization of a Yeast Chromosomal Replicator" Nature 282: 39-43 (1979).
Struhl, K., Stinchcomb, D., Scherer, S., & Davis R. "High-Frequency Transformation of Yeast: Autonomous Replication of Hybrid DNA Molecules" Proc. Natl. Acad. Sci. 76: 1035-1039 (1979).
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Chang Shing
Meade James H.
Cetus Corporation
Halluin Albert P.
Meyer Virginia H.
Scanlon William J.
Tanenholtz Alvin E.
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