Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1988-04-25
1990-02-20
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
514 2, 514 3, 514 4, 530302, 530303, 530311, 530350, 530351, A61K 4502, A61K 3702, C07K 1700, C07K 700
Patent
active
049025058
ABSTRACT:
Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the blood-brain barrier by transcytosis at a relatively high rate. The transportable peptide is conjugated to a hydrophilic neuropeptide which by itself is transportable only at a very low rate into the brain across the blood-brain barrier. The resulting chimeric peptide is transported into the brain at a much higher rate than the neuropeptide alone to thereby provide an effective means for introducing hydrophilic neuropeptides into the brain through the blood-brain barrier.
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Pardridge William M.
Schimmel Paul R.
Alkermes
Hazel Blondel
Regents of University of California
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