Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1986-07-30
1989-01-31
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 857, 514 2, 514 3, 530303, 530311, 530302, 530351, A61K 3702, C07K 1700, C07K 740
Patent
active
048015750
ABSTRACT:
Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the blood-brain barrier by transcytosis at a relatively high rate. The transportable peptide is conjugated to a hydrophilic neuropeptide which by itself is transportable only at a very low rate into the brain across the blood-brain barrier. The resulting chimeric peptide is transported into the brain at a much higher rate than the neuropeptide alone to thereby provide an effective means for introducing hydrophilic neuropeptides into the brain through the blood-brain barrier.
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Hazel Blondel
The Regents of the University of California
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