Chimeric peptides as immunogens, antibodies thereto, and...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S009100, C424S009200, C424S184100, C424S190100, C424S192100, C424S193100, C424S234100, C424S236100, C424S245100, C530S300000, C530S350000

Reexamination Certificate

active

07901689

ABSTRACT:
The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the precursor or mature protein are self molecules. The chimeric peptide or peptides have an end-specific B cell epitope from a naturally-occurring internal peptide cleavage product of a precursor or mature protein, as a free N- or C-terminus, fused with or without spacer residues to a T helper cell epitope derived from a living source different from that of the internal peptide cleavage product.

REFERENCES:
patent: 5879909 (1999-03-01), Perl
patent: WO98/23635 (1998-06-01), None
patent: 98/44955 (1998-10-01), None
patent: WO 99/27944 (1999-06-01), None
patent: WO-00/72876 (2000-12-01), None
patent: WO 00/72880 (2000-12-01), None
Schenk et al., “Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse”, Nature, 400.173 177 (Jul. 1999).
Sharma et al., “Co-dominant and reciprocal T-helper cell activity of epitopic sequences and formation of junctional B-cell determinants in synthetic T:B chimeric immunogens”, Vaccine, 11:1321-1326 (1993).
Ifversen et al., “Induction of primary antigen-specific immune responses in SCID-hu-PBL by coupled T-B epitopes”, Immunology, 84:111-116 (1995).
O'Hern et al., “Colinear synthesis of an antigen-specific B-cell epitope with a ‘promiscuous’ tetanus toxin T-cell epitope: a synthetic peptide immunocontraceptive”, Vaccine, 16:1761-1766 (1997).
Ho et al., “Identification of two promiscuous T cell epitopes from tetanus toxin”, Eur. J. Immunol., 20:477-483 (1990).
Panina-Bordignon et al., “University immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells”, Eur. J. Immunol., 19:2237-2242 (1989).
Valmori et al., “Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination”, The Journal of Immunology, 149:717-721 (Jul. 15, 1992).
Valmori et al., “Functional analysis of two tetanus toxin universal T cell epitopes in their interaction with DR1101 and DR1104 alleles”, Journal of Immunology, 2921-2929 (1994).
Schofield et al., “Sequences of the mouse F protein alleles and identification of a T cell epitope”, Eur. J. Immunol., 21:1235-1240 (1991).
Talwar et al. , “The HSD-hCG vaccine prevents pregnancy in women: feasibility study of a reversible safe contraceptive vaccine”, American Journal of Reproductive Immunology, 37:153-160 (1997).
Iwatsubo et al., “Short communication full-length amyloid-β(1-42(43)) and amino-terminally modified and truncated amyloid-β42(43) deposit in diffuse plaques”, American Journal of Pathology, 149:1823-1830 (Dec. 1996).
Brons et al, “Hierarchic T-Cell Help to Non-Linked B-Cell Epitopes”,Scand J Immunol44:478-484 (1996).
Delmas et al, “The binding of chimeric peptides to GM1 ganglioside enables induction of antibody responses after intranasal immunization”Vaccine14(11):1077-1082 (1996).
Frenkel et al, “N-terminal EFRH sequence of Alzheimer's β-amylold peptide represents the epitope of its anti-aggreating antibodies”,J Neuroimmunology88:85-90 (1998).
Partidos et al, “The influence of orientation and number of copies of T and B cell epitopes on the specificity and affinity of antibodies induced by chimeric peptides”,Eur J Immunol22:2675-2680 (1992).
Saido et al., “Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain,”Neurosience Letters 215:173-176 (1996).

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