Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1994-10-06
1997-04-08
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4242041, 4352351, 435 691, 435 693, 4352542, 4353201, 435236, 4353171, 435325, 435348, 536 2372, 536 234, 530412, 530413, A61K 3912, C12N 700, C12N 704, C12N 1537
Patent
active
056185367
ABSTRACT:
The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and related synthetic DNA molecules, host cells, methods and vaccines.
REFERENCES:
Crawford, Cancer Surveys 16, 215-228, 1993 Hawley in Fields Vinelogy p. 1627.
Alloub et al., (1989) Human papillomavirus infection and cervical intraepithelial neoplasia in women with renal allografts. Br. Med. Journal 298:153-156.
Baker et al. (1991) Structures of bovine and human papillomaviruses. Biophys J. 60:1445-1456.
Borisova et al. (1989) Recombinant core particles of hepatits B virus exposing foreign antigenic determinants on their surface. FEBS Letter 259:121-124.
Brown et al. (1994) Chimeric parvovirus B19 capsids for the presentation of foreign epitopes. Virology 198:477-488.
Chen et al. (1991) Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. Proc. Natl. Acad. Sci. 88:110-114.
Christensen, N.D. and Kreider, J. (1990) Antibody-Mediated neutralization in vivo of infectious papillomaviruses. Journal of Virology 64(7):3151-3156.
Christensen, N.D. and Kreider, J. (1993) Monoclonal antibody neutralization of BPV-1. Virus Research 28:195-202.
Christensen, N.D. et al. (1990) Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11. Journal of Virology 64:5678-5681.
Christensen, N.D. et al. (1991) The open reading frame L2 of cottontail rabbit papillomaviurs contains antibody-inducing neutralizing epitopes. Virology 181:572-579.
Dvoretzky et al. (1980) A quantitative in vitro focus assay for bovine papilloma virus. Virology 103:369-375.
Feltkemp et al. (1993) Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur. J. Immunol. 23:2242-2249.
Francis et al. (1990) Immunological properties of hepatitis B core antigen fusion proteins. Proc. Natl. Acad. Sci. 87:2545-2549.
Griffiths et al. (1991) Induction of high-titer neutralizing antibodies, using hybrid human immunodeficiency virus V3-Ty viruslike particles in a clinically relevant adjuvant. J. Virol. 65:450-456.
Hagensee et al. (1993) Self-assembly of human papillomavirus type 1 capsids by expression of the L1 protein alone or by coexpression of the L1 and L2 capsid proteins. J. Virol. 67:315-322.
Hartig, P.C. (1991) Generation of recombinant baculovirus via liposome-mediated transfection. Biotechniques 11:310-312.
Higuchi, R. (1990) Recombinant PCR. PCR Protocols; A guide to methods and applications p. 177.
Kirnbauer et al. (1994) A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16. Journal of the National Cancer Institute 86:494-499.
Kirnbauer et al. (1993) Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. Journal of Virology 67:6929-6936.
Kirnbauer et al. (1992) Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc. Natl. Acad. Sci. 89:12180-12184.
Laga et al. (1992) Genital papillomavirus infection and cervical dysplasia-opportunistic complications of HIV infection. Int. J. Cancer 50:45-48.
Michel et al. (1990) T- and B-lymphocyte responses to human immunodeficiency virus (HIV) type 1 in macaques immunized with hybrid HIV/hepatitis B surface antigen particles. J. Viro. 64:2452-2455.
Miyamura et al. (1994) Parvovirus particles as platforms for protein presentation. Proc. Natl. Acad. Sci. USA 91:8507-8511.
Mose Larson et al. (1987) Proteins present in bovine papillomavirus particles. J. Virol. 61:3596-3601.
Pilacinski et al. (1984) Cloning and expression in escherichia coli of the bovine papillomavirus L1 and L2 open reading frames. Bio/technology 2:356-360.
Roden et al. (1994) Interaction of papillomavirus with the cell surface. J. Virol. (in press).
Rose et al. (1993) Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of viruslike particles. J. Virol. 67:1936-1944.
Schiffman, M.H. (1992) Recent progress in defining the epidemiology of human papillomavirus infection and cervical neoplasia. J. Natl. Cancer Inst. 84:394-398.
Segre et al. (1955) Neutralization of bovine papilloma virus with serums from cattle and horses with experimental papillomas. Am. J. Vet. Res. 16:517-520.
Summers, M.D. & Smith, G.E. (1987) A manual of methods for baculovirus vectors and insect cell culture procedures, Texas Agricultural Experiment Station Bulletin vol. 1555.
Tindle et al. (1994) Chimeric hepatitis B core antigen particles containing B- and Th-epitopes of human papillomavirus type 16 E7 protein induced specific antibody and T-helper responses in immunised mice. Virology 200:547-557.
Viscidi et al. (1993) Serologic response in human papillomavirus-associated invasive cervical cancer. Int. J. Cancer 55:780-784.
Zur Hausen, H. (1991) Viruses in human cancers. Science 254:1167-1173.
Kirnbauer, R. et al. (1994) A vaccine of virus-like particles made in insect cells can inhibit papillomavirus infection of rabbits. 13th International Papillomavirus Conference. Amsterdam. The Netherlands.
Greenstone Heather
Lowy Douglas R.
Schiller John T.
Chen Michael C.
Mosher Mary E.
The United States of America as represented by the Department of
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