Chimeric pancreas

Details Chimeric pancreas Chimeric pancreas

2008-06-10

2008-06-10

Lankford, Jr., Leon B. (Department: 1651)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C435S001100, C514S866000

Reexamination Certificate

active

07384630

ABSTRACT:
Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said tissue into the peritoneal cavity of a mammalian recipient under conditions that allow the pancreatic tissue to become vascularized and mature, thereby developing a functioning chimeric, endocrine pancreas that produces at least insulin in the recipient. The invention also includes mammalian immature pancreatic tissue adapted for transplantation into the peritoneal cavity of a mammalian recipient for increasing the pancreatic mass of the mammalian recipient as well as methods and compositions for treatment of the pancreatic tissue, recipient immunosuppression and recipient co-stimulatory blockade.

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Rogers et al, “Intraperitoneal Transplantation of Pancreatic Anlagen” ASAIO Journal, 2003, vol. 49, No. 5, pp. 527-532.
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