Chimeric oligonucleoside compounds

Details Chimeric oligonucleoside compounds Chimeric oligonucleoside compounds

1997-10-27

2000-05-09

Riley, Jezia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 435 911, 514 1, 536 221, 536 231, 536 253, 536 241, 536 242, 536 243, 536 2432, 536 2431, 536 2433, C12Q 168, A01N 4304, C07H 1900, C07H 2100

Patent

active

060604565

ABSTRACT:
Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target ribonucleic acid sequences, and in treating disease conditions relating to such sequences.

REFERENCES:
patent: 5212295 (1993-05-01), Cook
patent: 5220007 (1993-06-01), Pederson et al.
patent: 5470967 (1995-11-01), Huie et al.
Bower et al. "Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp--Rp and Sp--Sp methylphosphonate (Me) modified duplexes of {d[GGAATCC]}.sub.2 "Nucleic Acids Research, vol. 15, pp. 4915-4930, 1987.
Akhtar et al. "Stability of antisense DNA oligodeoxinucleotide analogs in cellular extracts and sera" Life Science, vol. 49, pp. 1793-1801, 1991.

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