Chimeric nucleic acids and proteins for inhibiting HIV-1 express

Details Chimeric nucleic acids and proteins for inhibiting HIV-1 express Chimeric nucleic acids and proteins for inhibiting HIV-1 express

1995-06-06

1998-12-01

Elliott, George C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530350, 536 234, 4352523, 4353201, 4353723, C07K 1400, C12N 1540, C12N 1563, C12N 510

Patent

active

058437240

ABSTRACT:
A chimeric nucleic acid molecule encoding an NS1-Rev fusion protein having Rev function inhibitory activity.

REFERENCES:
patent: 5174993 (1992-12-01), Paolette
Johnston et al. (May 1993) Present status and future prospects for HIV therapies. Science 260:1286-1293.
Fox (Feb. 1994) No winners against AIDS. Bio/Technology 12:128.
Orkin et al. (Dec. 1995) Report and recommendations of the panel to assess the NIH investment in research on gene therapy.
Qian (Apr. 1995) Dissertation Abstracts International 56/06-B:3045.
Irene Weichselbraun, et al., "Definition of the Human Immunodeficiency Virus Type 1 Rev and Human T-Cell Leukemia Virus Type 1 Rex Protein Activation Domain by Functional Exchange", Journal of Virology, Apr. 1992, pp. 2583-2587.
Bevec, Dorian, et al. , "Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator", Biochemistry, Proc. Natl. Acad. Sci., USA, vol. 89, pp. 9870-9874, Oct. 1992.
Zapp, Maria L., et al. "Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: A duel function for an arginine-rich binding motif", Biochemistry, Proc. Natl. Acad. Sci USA, vol. 88, pp. 7734-7738, Sep. 1991.
Felber, Barbara K., et al. "Rev protein of human immunodeficiency versus type 1 affects the stability and transport of the viral MRNA", Biochemistry, Proc. Natl. Acad. Sci. USA, vol. 86, pp. 1495-1499, Mar. 1989.
Madore, Steven J., et al., "Sequence Requirements for Rev Multimerization In Vivo", Virology vol. 202, pp. 186-194, 1994.
Hadzopoulou-Cladaras, Margarita, et al., "The rev(trs/art) Protein of Human Immunodeficiency Virus Type 1 Affects Viral mRNA and Protein Expression via cis-Acting Sequence in the env Region", Journal of Virology, pp. 1265-1274, Mar. 1989.
Malim, Michael H., et al., "HIV-1 Structural Gene Expression Requires the Binding of Multiple Rev Monomers to the Viral RRE: Implications for HIV-1 Latency", Cell, vol. 65, pp. 241-248, Apr. 19, 1991.
Fortes, Purificacion, et al., "Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport", The EMBO Journal, vol. 13, No. 3., pp. 704-712, 1994.
Mermer, Brion, et al., "Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells", Nucleic Acids Research, vol. 18, No. 8, pp. 2037-2044, 1990.
Malim, Michael H., "Stable Expression of Transdominant Rev Protein in Human T Cells Inhibits Human Immunodeficiency Virus Replication", J. Exp. Med., vol. 176, pp. 1197-1201, Oct. 1992.
Olsen, Henrik S., et al., "Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env MRNA is dependent on multimer formation mediated through a basic stretch of amino acids", Genes & Development, pp. 1357-1364, 1990.
Bogerd, Hal, et al. "Dominant Negative Mutants of Human T-Cell Leukemia Virus Type 1 Rex and Human Immunodeficiency Virus Type 1 Rev Fail to Multimerize In Vivo", Journal of Virology, pp. 2496-2502, May 1993.
Alonso-Caplen et al., 1992, Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA, Genes & Development 6:255-267).
Baltimore, 1988, Intracellular immunization, Nature 335:395-396.
Berchtold et al., 1994, Exchange of Functional Domains between Rev Proteins of HIV-1 and SIVmac239 Results in a Dominant Negative Phenotype, Virology 204:436-41.
Benoist and Chambon, 1981, In vivo sequence requirements of the SV40 early promoter region, Nature vol. 290:304-310.
Brinster et al., 1982, Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs, Nature vol. 296:39-42.
Ceccoli, J. et al., 1989, Encapsulation of the UV-DNA Repair Enzyme T4 Endonuclease V in Liposomes and Delivery to Human Cells, The Society for Investigative Dermatology, Inc. vol. 93:190-194.
Chaudhary et al., 1989, A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin, Nature 339:394-397.
Chomczynski et al., 1987, Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction, Analytical Biochemistry, 162:156-159.
Cullen, 1994, Infectious Agents & Disease 3(2-3):68-76.
Feinberg et al., 1986, HTLV-III Expression and Production Involve Complex Regulation at the Levels of Splicing and Translation of Viral RNA, Cell: vol. 46; 807-817.
Gunning, et al., 1987, A human .beta.-actin expression vector system directs high-level accumulation of antisense transcripts, Proc. Natl. Acad. Sci. USA, 84:4831-4835.
Hamm et al., 1990, Monomethylated Cap Structures Facilitate RNA Export from the Nucleus, Cell, vol. 63:109-118.
Hope et al., 1992, trans-Dominant Inhibition of Human Immunodeficiency Virus Type 1 Rev Occurs through Formation of Inactive Protein Complexes, Journal of Virology, vol. 66:1849-1855.
Huston et al., Protein Engineering of Single-Chain Fv Analogs and Fusion Proteins, Molecular Design and Modeling: Concepts and Applications, Part B, ed. J.J. Langone, Methods in Enzymology 203:46-88.
Karasuyama, H., et al., 1989, Autocrine Growth and Tumorigenicity of Interleukin 2-Dependent Helper T Cells Transfected with IL-2 Gene, J. Exp. Med, The Rockefeller University Press., vol. 169:13-25.
Klessig, D.F., et al., 1984, Introduction, Stable Integration, and Controlled Expression of a Chimeric Adenovirus Gene Whose Product Is Toxic to the Recipient Human Cell, Mol.ecular and Cellular Biology., vol. 4:1354-1362.
Lamb et al, 1980, Sequence of Interrupted and Uninterrupted mRAs and Cloned DNA Coding for the Two Overlapping Nonstructural Proteins of Influenza Virus, Cell 21:475-485.
Levy et al., 1992, Viral and Immunologic Factors in HIV Infection, The Medical Management of AIDS, Third Edition, Eds, Sandy et al., W.B. Saunders Company.
Lu et al., 1994, "The influenza virus NS1 protein: a novel inhibitor of pre-mRNA Splicing." Genes and Development 8:1817-1828.
Malim et al., 1989, Functional Dissection of the HIV-1 Rev Trans-Activator-Derivation of a Trans-Dominant Repressor of Rev Function, Cell vol. 58:205-214.
Malim et al., 1989, The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA, Nature, 338:254-257.
Malim et al., 1991, Mutational Definition of the Human Immunodeficiency Virus Type 1 Rev Activation Domain, Journal of Virology vol. 65:4248-4254.
Sambrook, J., et al., 1989: Molecular Cloning (A Laboratory Manual), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Mannino, R.J. et al., 1988, Liposome Mediated Gene Transfer, Biotechniques, vol. 6 No. 7:682-690.
Meyer et al., 1994, The HIV-1 Rev Trans-activator shuttles between the nucleus and the cytoplasm, Genes & Development, 8(13):1538-47.
Newton, A.C. and Huestis, W.H., 1988, Vesicle-to-Cell Protein Transfer: Insertion of Band 3, the Erythrocyte Anion Transporter, into Lymphoid Cells, Biochemistry, 27:4655-4659.
Qian et al., 1994, Two Functional Domains of the Influenza Virus NS1 Protein Are Required for Regulation of Nuclear Export of mRNA, Journal of Virology, 68(4):2433-2441.
Qiu Y. and Krug RM, 1994, The Influenza Virus NS1 Protein Is a Poly(A)-Binding Protein That Inhibits Nuclear Export of mRNAs Containing Poly(A), Journal of Virology, 68(4):2425-32.
Ratner et al., 1987, Complete Nucleotide Sequences of Functional Clones of the AIDS Virus, AIDS Research and Human Retroviruses, vol. 3:57-69.
Sadaie et al., 1984, Site-Directed Mutagenesis of Two-Trans-Regulatory Genes (tat-III, trs) of HIV-1, Science, vol. 239:910-914.
Shaw et al., 1987, Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome, Science vol. 226:1165-1171.
Sodroski et al., 1986, A second post-transcriptional trans-activator gene required for HTLV-III replication, Nature vol. 321:412-417.
Tanswell, A.K. et al., 1990, Response of fetal rat lung fibroblasts to elevated oxygen concentrations after liposome-mediated augmentation of antioxidant enzymes, Bioch

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