Chimeric mouse for human and mouse immune systems

Details Chimeric mouse for human and mouse immune systems Chimeric mouse for human and mouse immune systems

1996-10-29

1998-09-22

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 424 931, 800DIG5, C12N 1500, A01N 6300

Patent

active

058116354

ABSTRACT:
This invention is directed to a chimeric mouse capable of mounting murine cellular and humoral immune response, said chimeric mouse being tolerant of human tissue implanted therein. The chimeric mouse of this invention is capable of developing murine T cells and producing murine IgG antibodies, which T cells and antibodies are tolerant of the human tissue implanted in said mouse, thereby allowing for the challenge of said vaccinated mouse with human-specific pathogens and determining the capacity of the vaccine to protect the cells in said implanted tissue from infection. This invention is also directed to a method for the development of said chimeric mouse, as well as to the use of said chimeric mouse for the screening of vaccines for human-specific pathogens.

REFERENCES:
Poulsen et al. Nature 248: 247, 1974.
Taguchi et al 164: 60, 1986.
Huppes et al Eur. J. Immunol 22: 197, 1992.
McCune et al Science 241: 1632, 1988.
Kennedy et al J. of Immunology 148(6): 1620, 1992.
Kollmann et al. J. Exp. Med 177: 221, 1993.
"Development of Multiple Organ-Localized Autoimmune Diseases in Nude Mice After Reconstitution of T Cell Function by Rat Fetal Thymus Graft", by Taguchi et al., in J. Exp. Med., vol. 164, pp. 62-71 (Jul., 1986).
"Long-Term Human Hematopoiesis in the SCID-hu Mouse", by Namikawa et al., in J. Exp. Med., vol. 172, pp. 1055-1062 (Oct., 1990).
"The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function", by McCune et al., in Science, vol. 241, pp. 1632-1639 (Sep. 23, 1988).
"Transfer of a Functional Human Immune System to Mice with Severe Combined Immunodeficiency", by Mosier et al., in Nature, vol. 335, pp. 256-259 (Sep. 1988).

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