Chimeric monoclonal antibodies which neutralize HIV-1 infection

Details Chimeric monoclonal antibodies which neutralize HIV-1 infection Chimeric monoclonal antibodies which neutralize HIV-1 infection

1991-09-26

1999-11-09

Eisenschenk, F. C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

5303873, 53038885, 5303871, C12N 512, C07K 1600

Patent

active

059812788

ABSTRACT:
Monoclonal antibodies are revealed which bind to the gp 120 protein on the envelope of HIV-1. These antibodies neutralize HIV-1. They inhibit the rate of infection of T cells, and also inhibit syncytium formation. Further, the antibodies are group-specific and neutralize different strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment and prevention of AIDS and ARC.

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