Chimeric monoclonal antibodies which bind to the extracellular s

Details Chimeric monoclonal antibodies which bind to the extracellular s Chimeric monoclonal antibodies which bind to the extracellular s

1993-01-11

1994-03-08

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303879, 53038873, C07K 1528

Patent

active

052928675

ABSTRACT:
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. The epitope can be exploited for therapy and diagnosis. For example, antibodies or immunotoxins specific for the epitopes associated with the anchor domain of IgE can be used to selectively destroy IgE-bearing lymphocytes, thus blocking IgE-mediated allergic reactions.

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