Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1998-02-27
2000-01-25
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
435 691, 435 914, 4352351, 4353201, 4241861, 4241991, 4242021, 4242041, 4241921, 514 44, 530300, 530350, 5303894, 536 231, 536 2372, A61K 39295, C12N 1540, C07K 1408
Patent
active
060177594
ABSTRACT:
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal disease virus strain. The genetic epitopic determinants encode amino acids or amino acid sequences which define epitopes bound to by previously established monoclonal antibodies. The immunogens expressed by the cDNA may be employed to provide a vaccine against a plurality of IBDV strains. The epitopic determinant of IBDV lethal strains has been detected, and an immunogen for conferring immunity with respect thereto is disclosed. Similarly, a monoclonal antibody specific for IBDV lethal strains is identified, and a vaccine for passive immunization therewith is also disclosed. Immunogens exhibiting conformational epitopes, in the form of virus-like particles, are effective in the preparation of vaccines.
REFERENCES:
Journal of General Virology, vol. 70, pp. 1473-1481, 1989, K.J. Fahey, et al., "A Conformation Immunogen on VP-2 of Infectious Bursal Disease Virus That Induces Virus-Neutralizing Antibodies That Passively Protect Chickens".
Archives of Virology, vol. 120, pp. 193-205, 1991, C.D. Bayless, et al., "A Recombinant Fowlpox Virus That Expresses The VP2 Antigen of Infectious Disease Virus Induces Protection Against Mortality Caused By The Virus".
Journal of General Virology, vol. 74, pp. 1201-1206, 1993, V.N. Vakharia, et al., "Infectious Bursal Disease Virus Structural Proteins Expressed in a Baculovirus Recombinant Confer Protection in Chickens".
Mengel-Whersat Stephanie A.
Snyder David B.
Vakharia Vikram
Bui Phuong T
Stucker Jeffrey
University of Maryland College Park
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