Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1994-03-29
1998-08-04
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4242021, 4352351, 5303894, A61K 39295, C12N 1540, C07K 1408
Patent
active
057889708
ABSTRACT:
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal disease virus strain. The genetic epitopic determinants encode amino acids or amino acid sequences which define epitopes bound to by previously established monoclonal antibodies. The immunogens expressed by the cDNA may be employed to provide a vaccine against a plurality of IBDV strains. The epitopic determinant of IBDV lethal strains has been detected, and an immunogen for conferring immunity is disclosed. Similarly, a monoclonal antibody specific for IBDV lethal strains is identified, and a vaccine for passive immunization is also disclosed. Immunogens exhibiting conformational epitopes, in the form of virus-like particles, are effective in the preparation of vaccines.
REFERENCES:
Journal of General Virology, vol. 70, pp. 1473-1481, 1989, K.J. Fahey , et al., "A Conformation Immunogen on VP-2 of Infectious Bursal Disease Virus that Induces Virus-Neutralizing Antibodies that Passively Protect Chickens".
Archives of Virology, vol. 120, pp. 193-205, 1991, C.D. Bayless, et al., "A Recombinant Fowlpox Virus that Expresses the VP2 Antigen of Infectious Disease Virus Induces Protection Against Mortality Caused by the Virus".
Journal of General Virology, vol. 74, pp. 1201-1206, 1993, V.N. Vakharia, et al., "Infectious Bursal Disease Virus Structural Proteins Expressed in a Baculovirus Recombinant Confer Protection in Chickens".
Heine et al. "Infectious bursal disease virus structural protein VP2 . . . " Arch Virol (1993) 131:277-292.
Jagadish et al. "Expression and characterization of infections bursal disease virus . . . " Gene, 95 (1990) 179-186.
Heine et al. "Sequence analysis and expression of the host protective . . . " J Gen Virol (1991), 72, 1835-1843.
Mengel-Whersat Stephanie A.
Snyder David B.
Vakharia Vikram
Achutamurthy Ponnathapura
Bui Phuong T.
The University of Maryland College Park
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