Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1999-06-15
2000-12-05
Bui, Phuong T.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241411, 4241391, 4241591, 4241841, 4241851, 4241861, 4242041, 4242021, 4241921, 435 693, 4352351, 4353201, 435 71, 530350, 5303894, 5303883, 536 2372, A61K 3942, C07H 2104, C07K 1608
Patent
active
061563145
ABSTRACT:
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal disease virus strain. The genetic epitopic determinants encode amino acids or amino acid sequences which define epitopes bound to by previously established monoclonal antibodies. The immunogens expressed by the cDNA may be employed to provide a vaccine against a plurality of IBDV strains. The epitopic determinant of IBDV lethal strains has been detected, and an immunogen for conferring immunity with respect thereto is disclosed. Similarly, a monoclonal antibody specific for IBDV lethal strains is identified, and a vaccine for passive immunization therewith is also disclosed. Immunogens exhibiting conformational epitopes, in the form of virus-like particles, are effective in the preparation of vaccines.
REFERENCES:
patent: 5595912 (1997-01-01), Vakharia et al.
Snyder et al. Arch. Virol. (1992) vol. 127 : 89-101.
Journal of General Virology, vol. 70, pp. 1473-1481, 1989, K.J. Fahey, et al., "A Conformation Immunogen on VP-2 of Infectious Bursal Disease Virus That Induces Virus-Neutralizing Antibodies That Passively Protect Chickens".
Archives of Virology, vol. 120, pp. 193-205, 1991, C.D. Bayless, et al, "A Recombinant Fowlpox Virus That Expresses the VP2 Antigen of Infectious Desease Virus Induces Protection Against Mortality Caused by the Virus".
Journal of General Virology, vol. 74, pp. 1201-1206, 1993, V.N. Vakharia, et al., "Infectious Bursal Disease Virus Structural Proteins Expressed in a Baculovirus Recombinant Confer Protection in Chickens".
Mengel-Whersat Stephanie A.
Snyder David B.
Vakharia Vikram
Bui Phuong T.
The University of Maryland College Park
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