Chimeric immunoglobulin for CD4 receptors

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

Reexamination Certificate

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C424S143100, C424S144100, C424S154100, C424S173100, C424S801000, C424S809000, C530S387300, C530S387100, C530S388200, C530S388220, C530S385000, C530S867000, C530S866000

Reexamination Certificate

active

07037496

ABSTRACT:
Chimeric antibodies for CD4 receptor comprising a variable or antigen binding region of a non-human origin specific for CD4 receptor and a constant region of human origin are disclosed. These antibodies are useful as therapeutic agents for auto-immune disorders.

REFERENCES:
patent: 4381295 (1983-04-01), Kung et al.
patent: 4695459 (1987-09-01), Steinman et al.
patent: 0 125 023 (1984-11-01), None
patent: 0 171 496 (1986-02-01), None
patent: 0 173 494 (1986-03-01), None
patent: 0 200 412 (1986-12-01), None
patent: 0 240 344 (1987-10-01), None
patent: 0 365 209 (1990-04-01), None
patent: 0 394 827 (1990-10-01), None
patent: 0 511 308 (1992-11-01), None
patent: WO 86/01533 (1986-03-01), None
patent: WO 88/09181 (1988-12-01), None
patent: WO 90/12868 (1990-11-01), None
patent: WO 91/09966 (1991-07-01), None
patent: WO 91/09967 (1991-07-01), None
Taylor et al. , Chapter T4.14, from: “Leukocyte Typing III, White Cell Differentiation Antigens”, Oxford University Press, 1987, pp. 234-237.
Kong, Y. M., et al., “Pathogenic Mechanisms in Murine Autoimmune Thyroiditis: Short- and Long-Term Effects of in vivo depletion of CD4+ and CD8+ Cells,”Clin. Exp. Immunol., 77:428-433 (1989).
Cobbold, S.P., et al., “Therapy with Monoclonal Antibodies by Elimination of T-Cell Subsets in vivo,”Nature, 312:548-551 (1984).
Mudgett-Hunter, M., et al., “Binding and Structural Diversity Among High-Affinity Monoclonal Anti-Digoxin Antibodies,”Molecular Immunology, 22(4):477-488 (1985).
Playfair, J.H.L., “Antigen-Antibody Interaction and Immune Complexes,” InImmunology At a Glance, (Blackwell Scientific Publication; London), Chapter 14 (1984).
Evans, R.L., et al., “Thymus-Dependent Membrane Antigens in Man: Inhibition of Cell-Mediated Lympholysis by Monoclonal Antibodies to TH2Antigen,”Proc. Natl. Acad. Sci., 78(1):544-548 (1981).
Matthews, T.J., et al., “AIDS Vaccines”,Scientific American, 259(4):98-105 (1988).
van Oosten, B. W., et al., “Treatment of Multiple Sclerosis with the Monoclonal Anti-CD4 Antibody cM-T412: Results of a Randomized, Double-Blind, Placebo-Controlled, MR-Monitored Phase II Trial,”Neurology, 49:351-357 (1997).
Moreland, L. W., et al., “Experience with a Chimeric Monoclonal Anti-CD4 Antibody in the Treatment of Refractory Rheumatoid Arthritis,”Clinical and Experimental Rheumatology, 11(Suppl. 8):S153-S159 (1993).
Gill, H.S., et al., “In vivo Inhibition by a Monoclonal Antibody to CD4+T Cells of Humoral and Cellular Immunity in Sheep,”Immunology, 77:38-42 (1992).
Bushell, A., et al., “Transplantation Tolerance Induced by Antigen Pretreatment and Depleting Anti-CD4 Antibody Depends on CD4+T Cell Regulation During the Induction Phase of the Response,”Eur. J. Immunol., 25:2643-2649 (1995).
Matloubian, M., et al., “CD4+Cells are Required to Sustain CD8+Cytotoxic T-Cell Responses During Chronic Viral Infection,”Journal of Virology, 68(12):8056-8063 (1994).
Canva-Delcambre, V., et al., “Treatment of Severe Crohn's Disease with Anti-CD4 Monoclonal Antibody,”Ailment Pharmacol. Ther., 10:721-727 (1996).
van Montfrans, C., et al., “Immunotherapy of Crohn's Disease,”Mediators of Inflammation, 7:149-152.
Reiter, C., et al., “Treatment of Rheumatoid Arthritis with Monoclonal CD4 Antibody M-T151. Clinical Results and Immunopharmacologic Effects in an Open Study, Including Repeated Administration,”Arthritis and Rheumatism, 34(5):525-536 (1991).
Moreland, L. W., et al., “Use of a Chimeric Monoclonal Anti-CD4 Antibody in Patients with Refractory Rheumatoid Arthritis,”Arthritis and Rheumatism, 36(3):307-318 (1993).
Boehringer Mannheim Biochemicals Catalogue, p. 328, 1987/1988.
Boehringer Mannheim Biochemicals Catalogue, p. 109, 1989.
Genbank Accession No. PH1224, “Ig Kappa Chain Precursor V Region (M-T151)—Mouse (fragment),” (1999) [online], [retrieved on Apr. 10, 2000]. Retreived from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. PH1225, “Ig Heavy Chain Precursor V Region (M-T151)—Mouse (fragment),” (1999) [online], [retrieved on Apr. 10, 2000]. Retreived from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. S19970, “Ig Kappa Chain V Region (M-T151)—Mouse (fragment),” (1999) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. S19963, “Ig Heavy Chain V Region (M-T151)—Mouse)fragment),” (1996) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. CAA46223, “Alpha CD4 mAb Immunoglobulin Light Chain VJ Region [Mus musculus],” (1997) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. CAA46215, “Alpha CD4 mAb Immunoglobulin Heavy Chain VDJ Region [Mus Musculus],” (1997) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. AAB24319, “Anti-CD4 mAb M-T151 Variable Region Heavy Chain <J4, Chimeric Antibody> [Mice, Hybridoma Cells, Peptide Partial, 139 aa],” (1993) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. AAB24318, “Anti-CD4 mAb M-T151 Variable Region Light Chain [J2, Chimeric Antibody] [Mice, Hybridoma Cells, Peptide Partial, 127 aa],” (1993) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. X65095, “M. musculus mRNA for IG Light Chain VJ Region (M-T151),” (1997) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. X65087, “M. musculus mRNA for IG Heavy Chain VDJ Region (M-T151),” (1997) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. S50263, “Ig VH=anti-CD4 mAb M-T151 Variable Region Heavy Chaim <J4, Chimeric Antibody> [Mice, Hybridoma Cells, mRNA Partial, 417 nt],” (1993) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Genbank Accession No. S50261, “Ig VL=anti-CD4 mAb M-T151 Variable Region Light Chain <J2, Chimeric Antibody> [Mice, Hybridoma Cells, mRNA Partial, 381 nt],” (1993) [online], [retrieved on Apr. 10, 2000]. Retrieved from www.ncbi.nlm.nih.gov:80.
Declaration of Dr. Christian Reiter executed on Nov. 2, 1994, filed in opposition proceeding in EP 0 511 308 (Reference AL3).
Declaration of Dr. Margaret R. Dalesandro executed on Jul. 1, 1998, filed in opposition proceeding in EP 0 511 308 (Reference AL3).
Sun, L.K., et al., “Chimeric Antibody with Human Constant Regions and Mouse Variable Regions Directed Against Carcinoma-Associated Antigen 17-1A,”Proc. Natl. Acad. Sci. USA, 84:214-218 (1987).
Morrison, S.L., et al., “Chimeric Human Antibody Molecules: Mouse Antigen-binding Domains with Human Constant Region Domains,”Proc. Natl. Acad. Sci. USA, 81:6851-6855 (1984).
Landau, N.R., et al., “The Envelope Glycoprotein of the Human Immunodeficiency Virus Binds to the Immunoglobulin-like Domain of CD4,”Nature, 334:159-162 (1988).
Wang, J., et al., “Atomic Structure of a Fragment of Human CD4 Containing Two Immunoglobulin-like Domains,”Nature, 348:411-418 (1990).
Ryu, S.E., et al., “Crustal Structure of an HIV-binding Recombinant Fragment of Human CD4,”Nature, 348:419-426 (1990).
Sattentau, Q.J., et al., “Epitopes of the CD4 Antigen and HIV Infection,”Science, 234:1120-1123 (1986).
Peterson, A., et al., “Genetic Analysis of Monoclonal Antibody and HIV Binding Sites on the Human Lymphocyte Antigen CD4,”Cell, 54:65-72 (1988).
Sattentau, Q.J., et al., “Structural Analysis of the Human Immunodeficiency Virus-binding Domain of CD4,”J. Exp. Med., 170:1319-1334 (1989).
Ashkenazi, A., et al., “Mapping the CD4 Binding Site for

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