Chimeric immunogenic gag-V3 virus-like particles of the human im

Details Chimeric immunogenic gag-V3 virus-like particles of the human im Chimeric immunogenic gag-V3 virus-like particles of the human im

1993-07-30

1996-12-03

Budens, Robert D.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4241881, 4242081, 435 5, 435 71, 435974, C12N 704, A61K 3921, G01N 3353, C12P 2106

Patent

active

055807739

ABSTRACT:
An unprocessed human immunodeficiency virus 2 (HIV-2) gag precursor protein, containing a deficient protease, assembles into virus-like particles by budding through the cytoplasmic domain of baculovirus-infected cells. Chimeric constructs were generated by coupling the truncated HIV-2 gag gene to the neutralizing domain (V3) or the neutralizing and CD4 binding domains (V3+CD4B) of gp120 env gene sequences obtained from HIV-1 or HIV-2. Virus-like particles were formed by chimeric gene products when the env gene sequences were linked to the 3' terminus of the gag gene. The gag-env chimeric proteins displayed immunoreactivity towards anti-gp120 rabbit antisera.

REFERENCES:
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Carrow et al., AIDS Res. and Hum. Retroviruses, 7, 831-838 (1991).
Katzenstein et al., J. AIDS, 3, 810-816 (1990).

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