Chimeric immunocompromised mammal comprosing vascularized fetal

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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800DIG5, 623 11, 424 92, 424553, 424578, 424579, 424 937, 424577, 424549, 424582, 424580, A61K 4900

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056399391

ABSTRACT:
Xenogeneic tissue is introduced into an immunocompromised host for interacting with agents and using such interaction for evaluating efficacy of drugs and vaccines, producing xenogeneic monoclonal antibodies, evaluating the effect of the various agents on specific tissues and the like. Particularly, drugs can be evaluated for their efficacy against a wide variety of pathogens which infect xenogeneic tissue, agents can be evaluated for their effect on the xenogeneic immune system and monoclonal antibodies to a predetermined epitope may be produced.

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