Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Reexamination Certificate
2006-03-28
2006-03-28
Mertz, Prema (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
C530S351000, C530S402000, C514S002600, C514S008100, C514S012200
Reexamination Certificate
active
07018626
ABSTRACT:
Disclosed are chimeric proteins having a cytokine fused to an enzymatically inactive polypeptide which increases the circulating half-life of the cytokine. The chimeric proteins are useful for treating, inhibiting, or preventing a variety of conditions, including septic shock, granulomatous disorders, Type I diabetes, and various cancers (e.g., multiple myeloma) in a patient.
REFERENCES:
patent: 5116964 (1992-05-01), Capon et al.
patent: 5196321 (1993-03-01), Bachmair et al.
patent: 5231012 (1993-07-01), Mosmann et al.
patent: 2045869 (1991-06-01), None
patent: 04 64 533 (1992-01-01), None
patent: 2686899 (1992-01-01), None
patent: WO 90 07932 (1990-07-01), None
patent: WO 94 04180 (1994-03-01), None
patent: WO94/08606 (1994-04-01), None
Laurence, D.R., “A Dictionary of Pharmacology and Allied Topics,” p. 90 (1998).
Rabinovitch, A., “Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM,” Diabetes, 43:613-621 (1994).
Steele, Alan W., et al.Structure and function in vitro and in vivo of a family of murine interleukin-2Fc... J. American Soc. Of Nephr. 4(3):636, 1993.
A. Traub, et al.Inerferon albumin conjugate with conserved biological activity, J. of General Virology 53:389-392, 1981.
Rene de Waal Malefyt, et al.Interleukin 10 (IL-10) and Viral IL-10 Strongly Reduce Antigen-specific Human T Cell Proliferation by Diminishing the Antigen... J. Exp. Med. 174:915-924, Oct., 1991.
Karl Byrne, et al.Adult Respiratory Distress Syndrome. Acute Care 13:206-234, 1987.
Roger C. Bone, M.D.The Pathogenesis of Sepsis. Annals of Internal Medicine, 115(6):457-469, Sep. 1991.
Catherine Gerard, et al.Interleukin 10 Reduces the Release of Tumor Necrosis Factor and Prevents Lethality in Experimental Endotoxemia. Journal of Experimental Medicine , 177(2):547-550, Feb. 1993.
David F. Fiorentino, et al.IL-10 Acts on the Antigen-Presenting Cell to Inhibit Cytokine Production by Th1 Cells. Journal of Immunology 146(10):3444-3451, May 1991.
David F. Fiorentino, et al.IL-10 Inhibits Cytokine Production by Activated Macrophages. Journal of Immunology 147(11):3815-3822, Dec. 1991.
Di-Hwei Hsu, et al.Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity. International Immunology 4(5):563-569, 1992.
Myung-Shik Lee, et al.Pancreatic Islet Production of Murine Interleukin-10 Does Not Inhibit Immune-mediated Tissue Destruction. Journal of Clinical Investigation 93:1332-1338, 1994.
Kevin W. Moore, et al.Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus bene BCRFI. Science 248:1230-1234, Jun. 1990.
Kevin W. Moore, et al.Interleukin-10. Annual Review of Immunology 11:165-190, 1993.
LuAnn Thompson-Snipes, et al.Interleukin-10: A Novel Stimulatory Factor for Mast Cells and Their Progenitors. Journal of Experimental Medicine 173(2):507-510, Feb. 1991.
Daniel J. Capon, et al.Designing CD4 immunoadhesins for Aids therapy. Nature 337:525-531, Feb. 1989.
1995 Cytokine Research Products Catalog, Genzyme Diagnostics; Cambridge, MA (Portions thereof.).
R. Doug Wagner, et al.Treatment with Anti-Interleukin-10 Monoclonal Antibody Enhances Early Resistance to but Impairs Complete Clearance of Listeria monocytogenes Infection in Mice, Infection and Immunity 62(6):2345-2353, Jun. 1994.
Kenneth J. Pennlike, et al.Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse. Clinical Immunology and Immunopathology 71(2): 169-175, May 1994.
Nicholas F. Landolfi, et al.A Chimeric IL-2/l1 Molecule Possesses the Functional Activity of Both Proteins. Journal of Immunology 146(3):915-919, Feb. 1991.
Alexander R. Duncan, et al.The binding site for Clq and IgGNature 332:738-740, Apr. 1988.
Alexander R. Duncan, et al.Localization of the binding site for the human high-affinity Fc receptor, on IgG. Nature 332:563-564, Apr. 1988.
Xin Xiao Zheng, et al.Administration of Noncytolytic IL-10/Fx in Murine Models of Lipopolysaccharide-Induced Septic Shock and Allogenic Islet Transplantation. Journal of Immunology 154:5590-5600,1995.
Pedro O. Flores Villanueva, et al.Role of IL-10 on Antigen-Presenting Cell Function for Schistosomal Egg-Specific Monoclonal T Helper Cell Responses in Vitro and in Vivo. Journal of Immunology 151(6):3192-3198, Sep. 1993.
Summons to Attend Oral Proceedings Pursuant to Rule 71(1) EPC for Application European Application No. 95943058.8, filed Dec. 12, 1995.
Steele Alan
Strom Terry B.
Zheng Xin Xiao
Beth Israel Deaconess Medical Center Inc.
Fish & Richardson P.C.
Mertz Prema
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