Chimeric IgG Fc receptors

Details Chimeric IgG Fc receptors Chimeric IgG Fc receptors

1994-07-12

1997-06-24

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 697, 536 234, C07K 1900, C07K 14705

Patent

active

056418639

ABSTRACT:
The present invention relates, in general, to methods of stimulating phagocytosis and thereby combating infection and/or modulating immune complex disease, in particular, to methods of modulating the number and type of Fc receptors present on cells that normally possess such receptors, including monocytes and macrophages, as well as on cells that normally do not possess Fc receptors, such as fibroblasts, and to compounds and compositions suitable for use in such methods.

REFERENCES:
Amigorena et al., Nature 358:337-341, 23 Jul. 1992.
Hibbs et al., P.N.A.S. 85:2240-2244, Apr. 1988.
Stuart et al, J. Exp. Med. 166:1668-1684, Dec. 1982.
Bonnerot et al., EMBO J. 11(7):2747-2758, Jul. 1982.
Yagi et al, "Cloning of the cDNA for the Deleted Syk Kinase Homologous to Zap-70 From Human Basophilic Leukemia Cell Line (KU812)", Biochemical and Biophysical Research Communications 200(1):28-34 (1994).
Mitchell et al, "Structural Requirements for Phagocytosis by the Fc Receptor Fc.gamma.RIIA", 1993 Clinical Research 41(2):189A.
Park et al, "The Structure of the .gamma. chain Fc Receptor Subunit Determines Phagocytic Function of Macrophage Fc.gamma.RIII (Fc.gamma.RIIIA)", 1993 Clinical Research 41(2):324A.
Mantaring et al, "The B-Cell Antigen Receptor Subunit Ig-.alpha. Mediates A Phagocytic Signal", 1993 Clinical Research 41(2):134A.
Rossman et al, "Alterations in Monocyte/Macrophage Fc.gamma. Receptor Expression in the Acute Respiratory Distress Syndrome (ARDS)", 1993 Clinical Research 41(2):251A.
Indik et al, "The High Affinity Fc.gamma. (CD64) Induces Phagocytosis in the Absence of its Cytoplasmic Domain", 1993 Clinical Research 41(2).
Indik et al, "Human Fc.gamma.RII: The Structure of the Fc.gamma.RII Cytosolic Domain Governs Phagocytic Function", 1992 Clinical Research 40(2):349A.
Indik et al, "The Structure of the Fc.gamma.RII Cytosolic Domain Influences Phagocytosis", 1992 FASEB J. 6(5):1613 Abstract.
Mitchell et al, "Structural Requirements of the Human Fc Receptor FC.gamma.RIIA in Phagocytosis", 1993 AAI/CIS Abstract J. Immunol. 150(8) Part 2 306A.
Hunter et al, "Fc.gamma.RIII Mediated Phagocytosis and Receptor Phosphorylation Does Not Require The Protein Tyrosine Kinase Src.", Clinical Research 41(2):244A.
Munn et al, "Role of Low-Affinity Fc Receptors in Antibody-dependent Tumor Cell Phagocytosis by Human Monocyte-derived Macrophages", Cancer Research 51:1117-1123 (1991).
Friedman, "Progress Toward Human Gene Therapy", Science 244:1275-1281 (1989).
Friedman et al, "Effect of Estradiol and Steroid Analogues on the Clearance of Immunoglobulin G-coated Erythrocytes", J. Clin. Invest. 75:162-167 (1985).
Indik et al, "Human Fc.gamma.RII, in the Absence of Other Fc.gamma. Receptors, Mediates a Phagocytic Signal", J. Clin. Invest. 88:1766-1771 (1991).
Rosenberg, Steven A., "Newer Approaches to Cancer Treatment", Cancer: Principles & Practice of Oncology, Fourth Edition, 2:2598-2613.
Amigorena et al, "Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presnetation via type III receptors for IgG", Nature 358:337-341 (1992).
Cassel et al, "Differential Expression of Fc.gamma.RIIA, Fc.gamma.RIIB and Fc.gamma.RIIC in Hematopoietic Cells" Analysis of Transcripts, Molecular Immunology 30(5):451-460 (1993).
Anderson, "Prospects for Human Gene Therapy", Science 226:401-409 (1984).
Pound et al, "Human Fc.gamma.RI Triggering of the Mononuclear Phagocyte Respiratory Burst", Molecular Immunology 30(5):469-478 (1993).
Agarwal et al, "Involvement of p72.sup.syk, a Protein-Tyrosine Kinase, in Fc.gamma. Receptor", The Journal of Biological Chemistry 268(21):15900-15905 (1993).
Rossi and Sarver, "RNA enzymes (ribozymes) as antiviral therapeutic agents", TIBTECH 8:179-183 (1990).
Akerley III et al, "Neutrophil Activation Trhough High-Affinity Fc.gamma. Receptor Using a Monomeric Antibody With Unique Properties", Blood 77(3):607-615 (1991).
Shohat et al, "Inhibition of cell growth mediated by plasmids encoding p53 anti-sense", Oncogene 1:277-283 (1987).
Indik et al, "Examination of Phagocytosis by Chimeric Fc.gamma. Receptors", Journal of Immunology 150(8), Part II, issued Apr. 15, 1993, p. 306A, abstract No. 1754.
Ruiz et al, "Structural Features of the In Vivo Steroid Effect on Macrophage Fc.gamma. Receptors", FASEB J. 4:A1758 (1990).
Indik et al, "Examination of Phagocytosis by Chimeric Fc.gamma. Receptors", J. Immunol. 150:306A (1993).
Ruiz et al, "Macrophage Fc.gamma. Receptor Expression: In Vivo Regulation by Human Recombinant Macrophage Colony Stimulating Factor (hrM-CSF)", Clin. Res. 40:796A (1992).
Ruiz et al, "Hormonal Regulation of Macrophage Fc.gamma. Receptor Expression In Vivo", Clin. Res. 38:367A (1990).
Keller et al, "Fc.gamma.RIIA is the Platelet Fc Receptor" Blood 211:55a (1992).
Huang et al, "Activation of the Platelet Fc.gamma. Receptor by Anti-Platelet Antibodies", Blood 210:55a (1992).
Park et al, "Mapping the Structure of the Fc Receptor, Fc.gamma.RIIIA, Required for Phagocytosis", Blood 996:251a (1992).
Darby et al, "Macrophage Fc.gamma.RIII Signaling Induces Protein Tyrosine Kinase Activation", Blood 1398:352a (1992).
Mitchell et al, "Structure-Function Relationships of the Fc.gamma. Receptor, Fc.gamma.RIIA, In Transmission of a Phagocytic Signal", Blood 627:159a (1992).
Tuijnman et al, "Human Low-Affinity IgG Receptor Fc.gamma.RIIa (CD32) Introduced Into Mouse Fibroblasts Mediates Phagocytosis of Sensitized Erythrocytes", Blood 79(7):1651-1656 (1992).
Comber et al, "Modulation of the Transcriptional Rate of Fc.gamma. Receptor mRNA in Human Mononuclear Phagocytes", Cellular Immunology 145:324-338 (1992).
Cines et al, "Immune Thrombocytopenic Purpura and Pregnancy", New England Journal of Medicine 306:826-831 (1982).
Schreiber et al, "Effect of Danazol in Immune Thrombocytopenic Purpura", New England Journal of Medicine 316:503-508 (1987).
Rossman et al, "Modulation of Fc.gamma. Receptors on the Human Macrophage Cell Line U-937", Cellular Immunology 119:174-187 (1989).
Tomer et al, "Menstrual cyclic thrombocytopenia", British Journal of Hematology 71:519-524 (1989).
Comber et al, "Receptors for the Fc Portion of Immunoglobulin G (Fc.gamma.R) on Human Monocytes and Macrophages", Biochemistry of the Acute Allergic Reactions: Fifth International Symposium, pp. 273-285 (1989).
Comber et al, "Modulation of Human Mononuclear Phagocyte Fc.gamma.RII mRNA and Protein", Cellular Immunology 124:292-307 (1989).
Hunter et al, "Fc.gamma.RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src", Experimental Hematology 21:1492-1497 (1993).
Darby et al, "Regulation of Fc.gamma.RIII Generation of Cultured Human Monocytes", FASEB J. 4:1258 (1990).
Schreiber et al, "Autoimmune Hemolytic Anemia", Hematology 4th Ed., Eds. Nathan et al, pp. 496-510 (1993).
Bussel and Schreiber, "Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Postransfusion Purpura", Hematology, Basic Principles and Practice, Ed. Hobbmann et al, pp. 1485-1494 (1991).
King et al, "Characterization of Fc.gamma. Receptors on a Human Erythroleukemia Cell Line (HEL)", Exp. Hematol. 20:576-581 (1992).
Schreiber et al, "The Immunobiology of Human Fc.gamma. Receptors on Hematopoietic Cells and Tissue Macrophages", Clinical Immunology and Immunopathology 62(1):566-572 (1992).
Rossman et al, "Modulation of macrophage Fc.gamma. receptors by rGM-CSF", Experimental Hematology 21: (1993).
Indik et al, "Human Fc.gamma.yRII: The Structure of the Fc.gamma.RII Cytosolic Domain Governs Phagocytic Function", Transactions of the Association of American Physicians CV:214-221 (1992).
Brennan et al, "Binding of IgG Containing Immune Complexes to Human Neutrophil Fc.gamma.RII and Fc.gamma.RIII Induces Actin Polymerization by a Pertussis Toxin-Insensitive Transduction Pathway", The Journal of Immunology 146(12):4282-4288 (1991).
Ruiz et al, "In Vivo Glucocorticoid Modulation of Guinea Pig Splenic Macrophage Fc.gamma. Receptors", J. Clin. Invest. 88:149-157 (1991).
Huang et al, "Activation of Fc.gamma.RII Induces Tyrosine Phospho

Affiliated with

Also associated with

Rating

Chimeric IgG Fc receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric IgG Fc receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric IgG Fc receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-149967