Chimeric human growth hormone derived from the placenta and...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S069400, C435S325000, C435S243000, C435S252330, C435S320100, C536S023400, C536S023510

Reexamination Certificate

active

07820409

ABSTRACT:
A way to increase the production of recombinant polypeptides by combining pieces of several different isoforms of a given gene to make a chimeric isoform of the gene (using a chimeric gene can increase the production of polypeptide over 25%), or by inserting several copies of the coding region in tandem into a transformation vector (e.g., plasmids carrying multiple copies of the chimera of SEQ ID NO: 3 increased production 107%).

REFERENCES:
patent: 3853832 (1974-12-01), Li
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 4446235 (1984-05-01), Seeburg
patent: 4601980 (1986-07-01), Goeddel et al.
patent: 4604359 (1986-08-01), Goeddel et al.
patent: 4665160 (1987-05-01), Seeburg
patent: 4670393 (1987-06-01), Seeburg
patent: 4745069 (1988-05-01), Mayne et al.
patent: 4755465 (1988-07-01), Gray et al.
patent: 4859600 (1989-08-01), Gray et al.
patent: 4859765 (1989-08-01), Nestor, Jr. et al.
patent: 5047333 (1991-09-01), Grandi et al.
patent: 5279947 (1994-01-01), Legoux et al.
patent: 5496713 (1996-03-01), Honjo et al.
patent: 5597709 (1997-01-01), Rosen et al.
patent: 5618697 (1997-04-01), Dalboge et al.
patent: 5633352 (1997-05-01), Dalboge et al.
patent: 5635604 (1997-06-01), Dalboge et al.
patent: 5688666 (1997-11-01), Bass et al.
patent: 5789199 (1998-08-01), Joly et al.
patent: 5849535 (1998-12-01), Cunningham et al.
patent: 5955323 (1999-09-01), Chen et al.
patent: 5955346 (1999-09-01), Wells et al.
patent: 6436674 (2002-08-01), Honjo et al.
patent: 7045318 (2006-05-01), Ballance
patent: 0489711 (1992-06-01), None
patent: 0587427 (1994-03-01), None
patent: 0974654 (2004-01-01), None
patent: 2055382 (1981-03-01), None
patent: 60045595 (1985-03-01), None
patent: 61202689 (1986-09-01), None
patent: 61224988 (1986-10-01), None
patent: 910000458 (1991-01-01), None
patent: 910000459 (1991-01-01), None
patent: WO9115589 (1991-10-01), None
Accession No. CD512745 (NIH-MGC http://mgc.nci.nih.gov/ , Jun. 6, 2003).
Joseph A. Martial et al., “Human Growth Hormone: Complimentary DNA Cloning . . . ,” 205 Science 602 (1979).
M.C. Lacroix et al., “Human Placental Growth Hormone—A Review,” 23 Placenta (Supplement A) S87 (2002) (Elsevier Science Ltd., publ.).
Alexey A. Schulga et al., “Increased Stability of Human Growth Hormone . . . ,” 528 FEBS Letters 257 (2002) (Elsevier Science B.V., publ.).
Gregory L. Gray et al., “Periplasmic Production of Correctly Processed Human Growth Hormone . . . ,” 39 Gene 247 (1985) (Elsevier Science publ.).
Chen, E.Y., et al., “The Growth Hormone Locus: Nucleotide Sequence, Biology and Evolution,” Genomics (1989) 4: 479-497.
Seeburg, P.H., “The Human Growth Hormone Gene Family: Nucleotide Sequence Shows Recent Divergence and Predict a New Polypeptide Hormone,” DNA (1982) 1: 239-249.
Hennen, G., et al., “A Human Placental GH: Increasing Levels During Second Half of Pregnancy with Pituitary GH Suppression as Revealed by Monoclonal Antibody Assays,” Intl. J. of Fertility (1985) 30: 27-33.
Macleod, J.N., et al., “Human Growth Hormone Variant is a Biologically Active Somatogen and Lactogen,” Endocrinology (1991) 128: 1298-1302.
Frankenne F., et al., “ Identification of Placental Human Growth Hormone as the Growth Hormone-V Gene Expression Product,” J. of Clinical Endocrinology and Metabolism (1990) 71:15-18.
Cooke, N. K., et al., “Two Distinct Species of Human Growth Hormone-Varient mRNA in the Human Placenta Predict the Expression of Novel Growth Hormone Proteins,” J. of Biol. Chem. (1988) 263: 9001-9006.
Denoto, F.M., et al., “Human Growth Hormone DNA Sequence and mRNA Structure: Possible Alternative Splicing,” Nucleic Acids Research (1981), 0: 3719-3730.
Untergasser, G., et al., “Complex Alternative Splicing of the GH-V Gene in the Human Testis,” Eur. J. of Endocrinology (1998) 139: 424-427.
Patel, N., et al., “Glucose Inhibits Human Placental GH Secretion, in vitro,” J. of Clinical Endocrinology and Metabolism (1995) 80: 1743-1746.
Lytras, A., et al., “Detection of Placental Growth Hormone Variant and chorionic Somatomammotropin Ribonucleic Acid Expression in Human Trophoblastic Neoplasm by Reverse Transcriptase-Polymerase Chain Reaction,” Endocrinology (1994) 134: 2461-2467.
Henner, G., “Human Placental Growth Hormone—From Basic Research to (in vitro) Diagnostics,” Global Healthcare (2002) 1-2.
Igout, A., et al., “Cloning and Nucleotide Sequence of Placental hGH-V cDNA,” Arch. Int. Physiol Biochim (1988) 96: 63-67.
Wood, P., “Growth Hormone: Its Measurement and the Need for Assay Harmonization,” Ann. Clin Biochem. (2001) 38:471-482.
Cunningham, B.C., et al., “Receptor and Antibody Epitopes in Human Growth Hormone Identified by Homolog-scanning Mutagenesis,” Science (1989) 243: 1330-1336.
Mukhija, R., et al., “High-level Production and One-step Purification of Biologically Active Human Growth Hormone inEscherichia coli,” Gene (1995) 165: 303-306.
Ucida, H., et al., “Secretion of Authentic 20-kDa Human Growth Hormone (20K hGH) inEscherichia coliand Properties of the Purified Product,” J. of Biotech. (1997) 55: 101-112.
Barsh, G.S., et al., “The Human Growth Hormone Gene Family: Structure and Evolution of the Chromosome Locus,” Nucleic Acids Res. (1983) 11: 3939-3958.
Lecomte, C.M., et al., “A New Natural hGH Variant 17.5 kd Produced by Alternative Splicing. An Additional Consensus Sequence, Which Might Play a Role in Branch Point Selection,” Nucleic Acids Res. (1987) 15: 6331-6348.
Goeddel, D., et al., “Direct Expression inEscherichia coliof a DNA Sequence Coding for Human Growth Hormone,” Nature (1979) 281: 544-548.
Lewis, U., “Variants of Growth Hormone and Prolactin and their Posttranslational Modifications,” Ann. Rev. Physiol. (1984) 46: 33-42.
Russell, J., et al., “Recombinant Hormones form Fragments of Human Growth Hormone and Human Placental Lactogen,” J. Biol. Chem. (1981) 256: 296-300.
Maxam, A.M. and Gilbert, W., “A New Method for Sequencing DNA,” Proc. Natl. Acad. Sci. USA (1977) 74: 560-564.
Sononick, D. “Alternative Splicing Caused by RNA Secondary Structure,” Cell (1985) 43: 667-676.
Singh, R.N.P, et al., “Heterogeneity of Human Growth Hormone,” Endocrinol. Res. Commun. (1974) 1: 449-484.
Lewis, U.J., et al., “The 20,000 Dalton Variant of Human Growth Hormone: Location of the Amino Acid Deletions,” Biochem. Biophys. Res. Commun. (1980) 92: 511-516.
Hirt, H., et al., “The Human Growth Hormone Gene Locus: Structure, Evolution and Allelic Variations,” DNA (1987) 6:59-70.
Parks, J.S., et al., “Evolution and Structure of the Growth Hormone Gene Cluster. In ‘Advances in Growth Hormone and Growth Factor Research’,” Ed. E. Meuller. Springer-Verlag (1989) 3-17.
Fiddes, J., et al., “Structure of Genes For Human Growth Hormone and Chorionic Somatomammotropin,” Proc. Natl. Acad. Sci. USA 76: 4294-4298.
Selby, M.J., et al., “Analysis of a Major Human Chorionic Somatomammotropin Gene. Evidence for Two Functional Promoter Elements,” J. of Biol. Chem. (1984) 259: 13131-13138.
Tanaka, T., et al., “A New Sensitive and Specific Bioassay for Lactogenic Hormones, Measurement of Prolactin and Growth Hormone in Human Serum,” Clin. Endocrinol. Metab. (1980) 51: 1058-1063.
Ealey, P.A., et al., “The Development of an Eluted Stain Bioassay (ESTA) for Human Growth Hormone,” Growth Regulation (1995) 5: 36-44.
Yanisch-Perron, C., et al., “Improved M13 Phage Cloning Vectors and Host Strains: Nucleotide Sequences of the M13mp18 and pUC19 Vectors,” Gene (1985) 33: 103-119.
Sambrook, J., Fritsch, E.F., and Maniatis, T., “Molecular Cloning: A Laboratory Manual (2nd Edition)” (1989) 1-1659.
Kraft, R., et al., “Using Mini-prep Plasmid DN

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