Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-05-12
2000-02-15
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 231, 530350, C12N 1511, C07K 1400, A61K 4800
Patent
active
06025341&
ABSTRACT:
Nucleic acid molecule that comprise an incomplete hepatitis C and hepatitis B viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome including a nucleotide sequence encoding a complete hepatitis C core protein and hepatitis B S gene protein operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis B virus and/or hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
REFERENCES:
patent: 5196194 (1993-03-01), Rutter et al.
patent: 5204096 (1993-04-01), Neurath et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5593972 (1997-01-01), Weiner et al.
Alter, M. et al., "The Natural History of Community-Acquired Hepatitis C in the United States", N. Eng. J. of Medicine, 1992, 327(27), 1899-1905.
Barry, M. et al., "Production of Monoclonal Antibodies by Genetic Immunization", BioTechniques, 1994, 16(4), 616, 618-19.
Bartenschlager, R. et al., "Nonstructural Protein 3 of the Hepatitis C Virus Encodes a Serine-Type Proteinase Required for Cleavage at the NS3/4 and NS4/5 Junctions", J. of Virol., 1993, 67, 3835-3844.
Blum, H. et al., "Hepatitis B Virus X Protein is not Central to the Viral Life Cycle in Vitro", J. of Virol., 1992, 66, 123-127.
Blum, H. et al., "Persistence of Hepatitis B Viral DNA After Seroligical Recovery from Hepatitis B Virus Infection", Hepatology, 1991, 14(1), 56-63.
Botarelli, P. et al., "T-Lymphocyte Response to Hepatitis C Virus in Different Clinical Courses of Infection", Gastroenterology, 1993, 104, 580-587.
Chen, H.-S. et al., "The Woodchuck Hepatitis Virus X Gene is Important for Establishment of Virus Infection in Woodchuck", J. Virology, 1993, 67(3), 1218-1226.
Chiba, J. et al., "Serodiagnosis of Hepatitis C Virus (HCV) Infection with an HCV Core Protein Molecularly Expressed by a Recombinant Baculovirus", PNAS USA, 1991, 88, 4641-4645.
Choo, Q.-L. et al., "Genetic Organization and Diversity of the Hepatitis C Virus", PNAS USA, 1991, 88, 2451-2455.
Bukh, J. et al., "Sequence Analysis of the Core Gene of 14 Hepatitis C Virus Genotypes", PNAS USA, 1994, 91, 8239-8234.
Bukh, J. et al., "Sequence Analysis of the 5' Noncoding Region of Hepatitis C Virus", PNAS USA, 1992, 89, 4942-4946.
Colombo, M. et al., "Prevalence of Antibodies to Hepatitis C Virus in Italian Patients with Hepatocellular Carcinoma", The Lancet, Oct. 28, 1989, 1006-1008.
Cox, G. et al., "Bovine Herpesvirus 1: Immune Responses in Mice and Cattle Injected with Plasmid DNA", J. Virology, 1993, 67(9), 5664-5667.
Davis, H. et al., "DNA-based Immunization Induces Continuous Secretion of Hepatitis B Surface Antigen and High Levels of Circulating Antibody", Human Molecular Genetics, 1993, 2(11), 1847-1851.
Farci, P. et al., "Lack of Protective Immunity Against Reinfection with Hepatitis C Virus", Science, 1992, 258, 135-140.
Ferrari, C. et al., "T-cell Response to Structural and Nonstructural Hepatitis C Virus Antigens in Persistent and Self-limited Hepatitis C Virus Infections", Hepatology, 1994, 19(2), 286-295.
Fynan, E.F. et al., "Use of DNA Encoding Influenza Hemagglutinin as an Avian Influenza Vaccine", DNA and Cell Biology, 1993, 12(9), 785-789.
Ganem, D. and Varmus, "The Molecular Biology of the Hepatitis B Viruses", Ann. Rev. Biochem., 1987, 56, 651-693.
Grakoui, A. et al., "Characterization of the Hepatitis C Virus-Encoded Serine Proteinase: Determination of Proteinase-Dependent Polyprotein Cleavage Sites", J. of Virol., 1993, 67, 2823-2843.
Han, J.H. et al., "Characterization of the Terminal Regions of Hepatitis C Viral RNA: Identification of Conserved Sequences in the 5' Untranslated Region and Poly(A) Tails at the 3' End", PNAS USA, 1991, 88, 1711-1715.
Heinz, F.X., "Comparative Molecular Biology of Flaviviruses and Hepatitis C Virus", Arch. Virol., 1992, 4, 163-171.
Hijikata, M. et al., "Gene Mapping of the Putative Structural Region of the Hepatitis C Virus Genome by in vitro Processing Analysis", PNAS USA, 1991, 88, 5547-5551.
Hosein, B. et al., "Improved Serodiagnosis of Hepatitis C Virus Infection with Synthetic Peptide Antigen from Capsie Protein", PNAS USA, 1991, 88, 3647-3651.
Houghton, M. et al., "Molecular Biology of the Hepatitis C Viruses: Implications for Diagnosis, Development and Control of Viral Disease", Hepatology, 1991, 14, 381-388.
Hsu, H. et al., "Characterization of Hepatitis C Virus Structural Proteins with a Recombinant Baculovirus Expression System", Hepatology, 1993, 17, 763-771.
Inchauspe, G. et al., "Genomic Structure of the Human Prototype Strain H of Hepatitis C Virus: Comparison with American and Japanese Isolates", PNAS USA, 1991, 88, 10292-10296.
Katayama, T. et al., "Improved Serodiagnosis of Non-A, Non-B Hepatitis by an Assay Detecting Antibody to Hepatitis C Virus Core Antigen", Hepatology, 1992, 15, 391-394.
Kato, N. et al., "Characterization of Hypervariable Regions in the Putative Envelope Protein of Hepatitis C Virus", Biochem. and Biophys. Res. Comm., 1992, 189(1), 119-127.
Kato, N. et al., "Molecular Cloning of the Human Hepatitis C Virus Genome from Japanese Patients with Non-A, Non-B Hepatitis", PNAS USA, 1990, 87, 9524-9528.
Kita, H. et al., "HLA B44-restricted Cytotoxic T Lymphocytes Recognizing and Epitope on Hepatitis C Virus Nucleocapsid Protein", Hepatology, 1993, 18, 1039-1044.
Korba, B. et al., "Hepatocellular Carcinoma in Woodchuck Hepatitis Virus-Infected Woodchucks: Presence of Viral DNA in Tumor Tissue from Chronic Carriers and Animals Serologically Recovered from Acute Infections", Hepatology, 1989, 9(3), 461-470.
Korba, B. et al., "Natural History of Woodchuck Hepatitis Virus Infections During the Course of Experimental Viral Infection: Molecular Virologic Features of the Liver and Lymphoid Tissues", J. Virology, 1989, 63(3), 1360-1370.
Koziel, M. et al., "Hepatitis C Virus (HCV)-Specific Cytotoxic T Lymphocytes Recognize Epitopes in the Core and Envelope Proteins of HCV", J. Virology, 1993, 67(12), 7522-7532.
Koziel, M. et al., "Intrahepatic Cytotoxic T Lymphocytes Specific for Hepatitis C Virus in Persons with Chronic Hepatitis", The J. of Immunology, 1992, 149, 3339-3344.
Manthorpe, M. et al., "Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice", Human Gene Therapy, 1993, 4, 419-431.
Martell, M. et al., "Hepatitis C Virus (HCV) Circulates as a Population of Different but Closely Related Genomes: Quasispecies Nature of HCV Genome Distribution", J. Virology, 1992, 66(5), 3225-3229.
Montgomery, D. et al., "Heterologous and Homologous Protection Against Influenza A by DNA Vaccination: Optimization of DNA Vectors", DNA and Cell Biology, 1993, 12(9), 777-783.
Nasoff, M. et al., "Identification of an Immunodominant Epitope Within the Capsid Protein of Hepatitis C Virus", PNAS USA, 1991, 88, 5462-5466.
Okamoto, H. et al., "Antibodies Against Synthetic Oligopeptides Deduced from the Putative Core Gene for the Diagnosis of Hepatitis C Virus Infection", Hepatology, 1992, 15, 180-186.
Okamoto, H. et al., "Nucleotide Sequence of the Genomic RNA of Hepatitis C Virus Isolated from a Human Carrier: Comparison with Reported Isolates for Conserved and Divergent Regions", J. Gen. Virol., 1991, 72, 2697-2704.
Okamoto, H. et al., "Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Sybtypes", J. Gen. Virol., 1988, 69, 2575-2583.
Saito, I. et al., "Hepatitis C Virus Infection is Associated with the Development of Hepatocellular Carcinoma", PNAS USA, 1990, 87, 6547-6549.
Schupper, H. et al., "Peripheral-blood Mononuclear Cell Responses to Recombinant Hepatitis C Virus Antigens in Patients with Chronic Hepatitis C", Hepatology, 1993, 18, 1055-1060.
Selby, M. et al., "Expression, Identification and Subcellular Localization of the Proteins Encoded by the Hepatitis C Viral Genome", J. Gen. Virol., 1993, 74, 1103-1113.
Santolini, E. et al., "Biosynthesis and Bioch
Tokushige Katsutoshi
Wakita Takaji
Wands Jack R.
Campell Bruce R.
Clark Deborah J. R.
The General Hospital Corporation
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