Chimeric hepatitis A vaccine

Details Chimeric hepatitis A vaccine Chimeric hepatitis A vaccine

1995-06-07

1998-11-17

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4242051, 4242251, 4352351, 4352361, 435237, 435320, 536 231, A61K 3929, A61K 3912, C12N 700, C12N 704

Patent

active

058372601

ABSTRACT:
A full-length cDNA copy of an attenuated, cell culture-adapted hepatitis-A virus genome has been constructed. The HAV cDNA when inserted, without the oligo (dG) oligo (dC) tails, into an RNA transcription vector yielded a plasmid designated pHAV/7. Transfection of monkey kidney cells with pHAV/7 DNA yielded HAV. Transfection with RNA transcripts produced in vitro from pHAV/7 yielded about 10-fold more HAV than transfection with pHAV/7 DNA. HAV thus produced are useful as a vaccine.

REFERENCES:
patent: 4164566 (1979-08-01), Provost et al.
patent: 5021348 (1991-06-01), Gieba et al.
Ticehurst, et al., (1983) Proc. Natl. Acad. Sci. USA 80:5885-5889.
Cohen, et al., (1987) Journal of Virology 61:50-59.
Cohen, et al., (1987) Proc. Natl. Acad. Sci. USA, 84:2497-2501.
Provost et al. (A) Proc. Soc. Exp. Bio. Med., 170:8-14, 1982.
Provost et al. (B) Proc. Soc. Exp. Bio. Med., 172:357-363, 1983.
Fienstone et al., Develop. Biol. Stano., 54:429-432, 1983.
Ticehurst et al., PNAS USA, 80:5885-5889, Oct. 1983.
Provost et al. (D) Proc. Soc. Exp. Bio. Med., 159:201-203, 1978.

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