Chimeric gene formed of the DNA sequences that encode the...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C424S192100, C424S269100

Reexamination Certificate

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11168874

ABSTRACT:
Chimeric gene formed by the DNA sequences that encode the antigenic determinants of four proteins ofL. infantum, useful for the serological diagnosis of canine Leishmaniosis and protein obtained, that consists of the prior employment of a cloning strategy. The patent describes the intermediate products generated during the process. A clone is achieved expressed in the protein rLiPO-Ct-Q (pPQI). To this initial vector, by means of the use of suitable restriction targets, DNA fragments are sequentially added that are encoded in other proteins and after each cloning step the correct orientation of each one of the inserts reduces the size of the expression products, the complete nucleotide sequence of the final pPQV clone being determined. A polypeptide is obtained with a molecular mass of 38 kD and with an isoelectric point of 7.37.

REFERENCES:
Ravindran et al (Current Molecule Medicine vol. 4, pp. 697-709, 2004).
Soto et al., GenEmbl Accession No. X68015: L. infantum LiP gene for acidic ribosomal protein LiP (Nov. 1993).
Soto et al.J. Clin. Microbiol1998, 36:58-63.
Plotkin et al (Vaccines, WB Saunders Company, 1988, pp. 571).

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