Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2005-08-16
2005-08-16
Navarro, Mark (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S192100, C424S193100, C424S265100, C424S269100, C530S350000
Reexamination Certificate
active
06929795
ABSTRACT:
Chimeric gene formed by the DNA sequences that encode the antigenic determinants of four proteins ofL. infantum, useful for the serological diagnosis of canine Leishmaniosis and protein obtained, that consists of the prior employment of a cloning strategy. The patent describes the intermediate products generated during the process. A clone is achieved expressed in the protein rLiPO-Ct-Q (pPQI). To this initial vector, by means of the use of suitable restriction targets, DNA fragments are sequentially added that are encoded in other proteins and after each cloning step the correct orientation of each one of the inserts reduces the size of the expression products, the complete nucleotide sequence of the final pPQV clone being determined. A polypeptide is obtained with a molecular mass of 38 kD and with an isoelectric point of 7.37.
REFERENCES:
Plotkin et al (Vaccines, W B Saunders Company, 1988, p. 571).
Soto et al., GenEmbl Accession No. X68015: L. infantum LiP gene for acidic ribosomal protein LiP (Nov. 1993).
Soto et al.J. Clin. Microbiol1998, 36:58-63.
Alvarez Manuel Soto
Bedate Carlos Alonso
Requena Rolania Jose Maria
Browdy and Neimark, PLC
C.B.F. Leti S.A.
Navarro Mark
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