Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Reexamination Certificate
2006-11-28
2006-11-28
Foley, Shanon (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
C536S023720, C536S024100
Reexamination Certificate
active
07141405
ABSTRACT:
The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of GB virus B (GBV-B)/HCV chimeras. The invention involves nucleic acid constructs and compositions encoding GBV-B/HCV chimera, including at least part of a 5′ NTR derived from a HCV 5′ NTR. This construct, and chimeric versions of it, may be employed to study GBV-B and related hepatitis family members, such as hepatitis C virus. The invention thus includes methods of preparing GBV-B/HCV chimeric sequences, constructs, and viruses, as well as methods of employing these compositions.
REFERENCES:
patent: 5807670 (1998-09-01), Muerhoff et al.
patent: 6627437 (2003-09-01), Traboni
patent: 2001/0034019 (2001-10-01), Hong et al.
patent: WO 00/75337 (2000-12-01), None
Yanagi et al., Virology, 262, 250-263 (1999).
Al et al., “Expression of recombinant hepatitis C virus non-structural protein 5B inEscherichia coli,” Virus Res., 53:141-149, 1998.
Beames et al., “Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C. virus,”J. Virol., 74:11764-11772, 2000.
Beard et al., “An infectious molecular clone of a Japanese genotype 1b hepatitis C virus,”Hepatology, 30:316-324, 1999.
Behrens et al., “Identification and properties of the RNA dependent RNA polymerase of hepatitis C virus,”EMBO J, 15:12-22, 1996.
Chambers et al., “Yellow fever/Japanese encephalitis chimeric viruses. construction and biological properties,”J Virol, 73:3095-3101, 1999.
Choo et al., “Vaccination of chimpanzees against infection by the hepatitis C virus,”Proc Natl Acad Sci USA, 91:1294-1298, 1994.
Farci et al., “Lack of protective immunity against reinfection with hepatitis c virus,”Science, 258:135-140. 1992.
Farci et al., “The natural history of infection with hepatitis C virus (HCV) in chimpanzees: Comparison of serologic responses measured with first- and second-generation assays and relationship to HCV viremia,”The Journal of Infectious Diseases, 165:1006-1011, 1992.
Filocamo et al., “Chimeric Sindbis viruses dependent on the NS3 protease of hepatitis C virus,”J. Virol, 71 1417-1427, 1997.
Frolov et al., “Cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5′ nontranslated region chimeras,”RNA4:1418-1435, 1998.
Hijikata et al., “Two distinct protease activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus,”J Virol, 67:4665-4675, 1993.
Honda et al., “Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA,”RNA, 2:955-968, 1996.
Karayiannis et al., “Studies of GB hepatitis agent in tamarins,”Hepatology, 9:186-192, 1989.
Kim et al., “Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide,”Cell, 87:343-355, 1996.
Kolykhalov et al., “Identification of a highly conserved element at the 3′ terminus of hepatitis C virus genome RNA,”J Virol, 70:3363-3371, 1996.
Kolykhalov et al., “Transmission of hepatitis C by intrahepatic inoculation of transcribed RNA,”Science, 277:570-574, 1997.
Lemon and Honda, “Internal ribosome entry sites within the RNA genomes of hepatitis C virus and other flaviviruses,”Seminars in Virology, 8:274-288, 1997.
Lu and Wimmer, “Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus,”Proc Natl Acad Sci USA, 93:1412-1417, 1996.
Muerhoff et al., “Genomic organisation of GB viruses A and B: Two new members of the flaviviridae associated with GB agent hepatitis,”J Virol, 69:5621-5630, 1995.
Pletnev et al., “Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses,”Proc. Natl Acad Sci USA ,89:10532-10536, 1992.
Reynolds et al., “Unique features of internal initiation of hepatitis C virus RNA translation,”EMBO J, 14:6010-6020, 1995.
Rijnbrand et al., “Mutational analysis of the GB virus B internal ribosome entry site,”J Virol, 74:773-783, 2000.
Scarselli et al., “GB virus B and hepatitis C virus share substrate specificity,”J Virol, 71:4985-4989, 1997.
Schlauder et al., “Molecular and serological analysis in the transmission of the GB hepatitis agent,”J Med Virol, 46:81-90, 1995.
Shaffer et al., “A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5′ nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection,”J Virol, 69:6600-6604, 1995.
Simons et al., “Identification of two flavivirus like genomes in the GB hepatitis agent,”Proc Natl Acad Sci, 92:3401-3405, 1995.
Tanaka et al., “A novel sequence found at the 3′ terminus of hepatitis C virus genome,”Biochem Biophys Res Comm, 215:744-749, 1995.
Todd et al., “Replication competent picornaviruses with complete genomic RNA 3′ non-coding deletions,”J Virol, 71:8868-8874, 1997.
Yanagi et al., “Transcripts from a single full length cdna clone of hepatitus c virus are infectious when directly transfected into a liver of a chimpanzee,”Proc Natl Acad Sci USA, 94:8738-8743, 1998.
Yao et al., “Structure of the hepatitis C virus RNA helicase domain,”Nature Structural Biology, 4:463-467, 1997.
Zhao et al., “Poliovirus/hepatitis C virus (internal ribosome entry site-core) chimeric viruses: improved growth properties through modification of a proteolytic cleavage site and requirement for core RNA sequence but not for core related polypeptides,”J Virol, 73:1546-1554, 1999.
Lemon Stanley M.
Martin Annette
Rijnbrand René
Sangar David V.
Board of Regents , The University of Texas System
Foley Shanon
Fulbright & Jaworski L.L.P.
Institut Pasteu
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