Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-06-20
2006-06-20
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S007210, C435S252300, C435S320100, C530S350000, C536S023400
Reexamination Certificate
active
07063966
ABSTRACT:
The present invention provides chimeric Edg receptors, useful as components of an assay system. The present invention also provide methods of screening for compounds that bind a chimeric Edg receptor, for example, by contacting a chimeric Edg receptor with a compound and detecting a change in chimeric Edg receptor-mediated activity such as calcium mobilization.
REFERENCES:
patent: WO 00/56135 (2000-09-01), None
Ancellin et al. Differential Pharmacological Properties and Signal Transduction of Sphingosine 1-phosphate Receptors EDG-1, EDG-3, and EDG-5. Jul. 2, 1999, J. Bio. Chem. 274(27):18997-19002.
Conway et al. Chimeric Melatonin mt1 and Melatonin-related Receptors. Jul. 7, 2000. J. Biol. Chem. 275(27):20602-20609.
Schoth et al. Chimeric MC! and MC3 Receptors: Identification of Domains Participating in Binding of Melanocyte-Stimulating Hormone Peptides. 1998. Mol. Pharm. 54:154-161.
Wu et al. First Intracellular Loop of the Human Cholecystokinin-A Receptor is Essential for Cyclic AMP Signalling in Transfected HEK-293 Cells. J. Biol. Chem. 272(14):9037-9042.
Meng et al. Mapping the Receptor Domains Critical for the Binding Selectivity of delta-opiod Receptor Ligands. 1996. Euro. J. Pharm. 311:285-292.
Holtzmann et al. Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptides Receptors. Jun. 16, 1995. J. Biol. Chem. 270(24):14394-14398.
Takagi et al. Structural Basis of G Protein Specificity of Human Endothelin Receptors. Apr. 28, 1995. 270(171):10072-10078.
Buggy et al. Glucagon-Glucagon-like Peptide l Receptor Chimeras Reveal Domains That Determine Specificity of Glucagon Binding. Mar. 31, 1995. J. Biol. Chem. 270(13):7474-7478.
Kim et al. Random Chimeragenesis of G-protein-coupled Receptors. Nov. 18, 1994. J. Biol. Chem. 269(46):28724-28731.
Gether et al. Chimeric NK1 (SubstanceP)/NK3 (Neurokinin B) Receptors. Apr. 15, 1993. J. Biol. Chem. 268(11):7893-7898.
MacLennan et al., 1994, “Cloning and Characterization of a putative G-Protein Coupled Receptor Potentially Involved in Development,”Molecular and Cellular Neuroscience5(3), 201-209.
Medici et al., 1997, “Efficient Signal Transduction By A Chimeric Yeast-Mammalian G Protein α subunit Gpa1-Gsα Covalently Fused to the Yeast Receptor Ste2,”EMBO J16, 7241-7249.
Sambrano et al., 1999, “The Carboxyl Tail of Protease-Activated Receptor-1 Is Required for Chemotaxis,”Journal of Biological Chemistry274(29), 20178-20184.
Jewell-Motz et al., 2000, “α2A/α2C-Adrenergic Receptor Third Loop Chimera Show That Agonist Interaction With Receptor Subtype Backbone Establishes G Protein-Coupled Receptor Kinase Phosphorylation,”Journal of Biological Chemistry275(37), 28989-28993.
Nanevicz et al., 1996, “Thrombin Receptor Activating Mutations,”Journal of Biological Chemistry271(2), 702-706.
Cypess et al., 1999, “Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium,”Journal of Biological Chemistry274(27), 19455-19464.
Hla, Timothy., 2001, “Sphingosine 1-Phosphate Receptors,”Prostaglandins&Other Lipid Mediators64 (2001) 135-142.
Weber,Michael-Wolf, 1999, “Ion Currents ofXenopus laevisOocyte: State of the Art,”Biochimica et Biophysica Acta1421, 213-233.
Bandoh et al., 2000,“Lysophosphatidic acid (LPA) Receptors of the EDG Family Are Differentially Activated by LPA Species,”FEBS Letters478 (2000) 159-165.
van Koppen et al., 1996,“Activation of a High Affinity Gi Protein-Coupled Plasma Membrane Receptor By Sphingosine-1-Phosphate,” Journal of Biological Chemistry 271(4) 2082-2087.
Van Brocklyn et al., 1998,“Dual Actions of Sphingosine-1-Phosphate: Extracellular Through the Gi-Coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival,”Journal of Cell Biology142(1) 229-240.
Gether, Ulrik., 2000,“Uncovering Molecular Mechanisms Involved In Activation of G Protein-Coupled Receptors,” Endocrine Reviews 21, 90-113.
Berridge et al., 2000,“The Versatility and Universality Of Calcium Signalling,”Nature Reviews1, 11-21.
Moolenaar et al., 1997,“Lysophosphatidic acid: G-protein Signalling and Cellular Responses,” Current Opinion in Cell Biology 9, 168-173.
Parill et al., 2000,“Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate,”Journal of Biological Chemistry275 (50), 39,379-39,384.
An et al., 1998,“Characterization of a Novel Subtype of Human G Protein-Coupled Receptor for Lysophoshatidic Acid,”Journal of Biological Chemistry273 (14), 7906-7910.
Bandoh et al., 1999,“Molecular Cloning and Characterization of a Novel Human G-Protein-Coupled Receptor, EDG7, for Lysophosphatidic Acid,”Journal of Biological Chemistry274(39), 27,776-27,785.
Kolakowski, Lee F., 1994,“GCRDb: A G-Protein-Coupled Receptor Database,”Receptors and Channels2, 1-7.
Verrall et al.,1997,“The Thrombin Receptor Second Cytoplasmic Loop Confers Coupling to Gq-Like G Proteins in Chimeric Receptors,”Journal of Biochemistry272(11) 6898-6902.
Im et al., Dec. 6, 2000, GenBank Accession No.: AF233365.
Yamaguchi et al., Jan. 8, 1997, GenBank Accession No.: X83864.
Graeler, M.H., Nov. 17, 1998, GenBank Accession No.: AJ000479.
Tigyi et al., Mar. 15, 2000, GenBank Accession No.: AF317676.
Moolenaar et al., Feb. 4, 1998, GenBank Accession No.: U78192.
Bandoh et al., Aug. 17, 2000, GenBank Accession No.: AF233092.
An et al., Jul. 29, 1998, GenBank Accession No.: AF011466.
MacLennan et al., Jan. 1, 1999, GenBank Accession No.: AF034780.
Bandoh et al., Sep. 25, 1999, GenBank Accession No.: AF127138.
International Search Report Corresponding to PCT/US02/22346, Oct. 21, 2002.
Hammerland et al., “Domains determining ligand specificity for Ca2+receptorts”, Molecular Pharmacology, (1999), 55:642-648.
Jutta et al., “Preservation of G1coupling of a chimeric EP3/I-type prostaglandin (IP) receptor”, Biochemical Pharmacology, (1999), 58:471-476.
Kobilka et al., “Chimeric α2-, β2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity”, Science, (1988) 240:1310-1316.
Liu et al., “Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1”, Molecular Biology of the Cell, (1999), 10:1179-1190.
Songzhu et al., “Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate”, Journal of Cellular Biochemistry Supplements, (1998), Suppl 30, 31:147-157.
Munning Jason N.
Shankar Geetha
Spencer Juliet V.
SRI - International
Ulm John
LandOfFree
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