Chimeric flaviviruses

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

Reexamination Certificate

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C424S218100, C435S005000

Reexamination Certificate

active

07459160

ABSTRACT:
The invention provides flavivirus vaccines and methods of making and using these vaccines.

REFERENCES:
patent: 6136561 (2000-10-01), Ivy et al.
patent: 6171854 (2001-01-01), Galler et al.
patent: 6184024 (2001-02-01), Lai et al.
patent: 6416763 (2002-07-01), McDonell et al.
patent: 6682883 (2004-01-01), Monath et al.
patent: 6878372 (2005-04-01), Monath et al.
patent: 2003/0044773 (2003-03-01), Kleanthous et al.
patent: 2003/0194801 (2003-10-01), Bonaldo et al.
patent: 2004/0223979 (2004-11-01), Chambers et al.
patent: 2004/0259224 (2004-12-01), Guirakhoo
patent: 2005/0002968 (2005-01-01), Monath et al.
patent: 2005/0053624 (2005-03-01), Arroyo et al.
patent: 2007/0184469 (2007-08-01), Depres et al.
patent: WO 93/06214 (1993-04-01), None
patent: WO 02/072835 (2002-09-01), None
patent: WO 02/102828 (2002-12-01), None
patent: WO 03/063725 (2003-08-01), None
patent: WO 03/101397 (2003-12-01), None
patent: WO 03/103571 (2003-12-01), None
patent: WO 2004/045529 (2004-06-01), None
patent: WO 2005/040390 (2005-05-01), None
patent: WO 2005/049815 (2005-06-01), None
patent: WO 2005/082020 (2005-09-01), None
patent: WO 2006/044857 (2006-04-01), None
patent: WO 2006/116182 (2006-11-01), None
patent: WO 2007/051267 (2007-05-01), None
Theiler, M. “The use of yellow fever virus modified by in vitro cultivation for human immunization” (Rev. Med. Virol. (2000), vol. 10, 3-16).
Caufour, P.S. “Construction, characterization and immunogenicity of recombinant yellow fever 17D-dengue tyhpe 2 viruses” (Virus Res. (Nov. 2001) vol. 79, 1-14).
Guirakhoo, F. “Recombinant Chimeric Yellow Fever-Dengue Type 2 Virus Is Immunogenic and Protective in Nonhuman Primates” (J. of Virol. (Jun. 2000) vol. 74, No. 12, 5477-5485).
Montath, T.P. “Chimeric Yellow Fever Virus 17D-Japanese Encephalitis virus Vaccine: Dose-Response Effectiveness and Extended Safety Testing inRhesusMonkeys” (J. of Virol. (Feb. 2000) vol. 74, No. 4, 1742).
Van Der Most, R.G. “Chimeric Yellow Fever/Dengue Virus as Candidate Dengue Vaccine: Quantification of the Dengue Virus-Specific CD8 T-Cell Response” (J. of Virol. (2000) vol. 74, No. 17, 8094-8101).
Barret, A.D. “Current Status of Flavivirus Vaccines” Ann. N.Y. Acad. Sci. (Dec. 2001) vol. 951, 262-271).
Monath, Thomas P. The Lancet, Infectious Diseases, Aug. 2001, 1:11-20.
Guirakhoo et al., Journal of Virology, May 2004, 78(9):4761-4775.
Rothman, Alan L. The Journal of Clinical Investigation, Apr. 2004 113(7):946-951.
Chen et al., “Generation and Characterization of Organ-Tropism Mutants of Japanese Encephalitis Virus in Vivo and in Vitro,” Virology 223:79-88, 1996.
Guirakhoo et al., “A Single Amino Acid Substitution in the Envelope Protein of Chimeric Yellow Fever-Dengue 1 Vaccine Virus Reduces Neurovirulence for Suckling Mice and Viremia/Viscerotropism for Monkeys,” J. Virology 78(18):9998-10008, 2004.
Lee et al., “Changes in the Dengue Virus Major Envelope Protein on Passaging and Their Localization on the Three-Dimensional Structure of the Protein,” Virology 232:281-290, 1997.
Arroyo et al., “Molecular Basis for Attentuation of Neurovirulence of a Yellow Fever Virus/Japanese Encephalitis Virus Chimera Vaccine (ChimeriVax-JE),” Journal of Virology 75:934-942, 2001.
Bray et al., “Genetic Determinants Responsible for Acquisition of Dengue Type 2 Virus Mouse Neurovirulence,” Journal of Virology 72:1647-1651, 1998.
Chambers et al., “Yellow Fever/Japanese Encephalitis Chimeric Viruses: Construction and Biological Properties,” Journal of Virology 73:3095-3101, 1999.
dos Santos et al., “Determinants in the Envelope E Protein and Viral RNA Helicase NS3 that Influence the Induction of Apoptosis in Response to Infection with Dengue Type 1 Virus,” Virology 274:292-3089, 2000.
Guirakhoo et al., “Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine,” Journal of Virology 75:7290-7304, 2001.
Hurrelbrink and McMinn, “Attenuation of Murray Valley Encephalitis Virus by Site-Directed Mutagenesis of the Hinge and Putative Receptor-Binding Regions of the Envelope Protein,” Journal of Virology 75:7692-7702, 2001.
Kanesa-thasan et al., “Safety and Immunogenicity of Attentuated Dengue Virus Vaccines (Aventis Pasteur) in Human Volunteers,” Vaccine 19:3179-3188, 2001.
McMinn, “The Molecular Basis of Virulence of the Encephalitogenic Flaviviruses,” Journal of General Virology 78:2711-2722, 1997.
Monath et al., “Single Mutation In the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Revelence to Development and Safety Testing of Live, Attenuated Vaccines,” Journal of Virology 76:1932-1943, 2002.
Monath, “Molecular Distinctions Between Attentuated (Vaccine) and Virulent Yellow Fever Viruses,” In, Plotkin SA and Orenstein WA (eds). Vaccines, 3rdedition, Saunders (Philadelphia), pp. 815-879, 1999.
Rey et al., “The Envelope Glycoprotein From Tick-Borne Encephalitis Virus at 2Å Resolution,” Nature 375:291-298, 1995.
Wang et al., “Comparison of the Genomes of the Wild-Type French Viscerotropic Strain of Yellow Fever Virus with its Vaccine Derivative French Neurotropic Vaccine,” Journal of General Virology 76:2749-2755, 1995.
Chambers et al., U.S. Appl. No. 09/452,638, filed Dec. 1, 1999.
Chambers et al., U.S. Appl. No. 09/121,587, filed Jul. 23, 1998.
Excerpt from Monath TP. “Yellow fever” In: Plotkin SA, Orenstein WA, eds. Vaccines. 3rd ed. Philadelphia, Pennsylvania: WB Saunders Company, p. 815-879, 1999.
Vlaycheva et al., “Yellow Fever 17D Virus: Pseudo-Revertant Suppression of Defective Virus Penetration and Spread by Mutuations in Domains II and III of the E protein,” Virology 327:41-49, 2004.
U.S. Appl. No. 08/807,445, filed Feb. 28, 1997, Chambers et al.
U.S. Appl. No. 09/007,664, filed Jan. 15, 1998, Chambers et al.
Allison et al., “Mapping of Functional Elements in the Stem-Anchor Region of Tick-Borne Encephalitis Virus Envelope Protein E,”J. Virology73:5605-5612, 1999.
Allison et al., “Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E,”J. Virology75:4268-4275, 2001.
Arroyo et al., “Yellow Fever Vector Live-Virus Vaccines: West Nile Virus Vaccine Deparment,”Trends Mol. Med.7:350-354, 2001.
Arroyo et al., “ChimeriVax-West Nile Virus Live-Attenuated Vaccine: Preclinical Evaluation of Safety, Immunogenicity, and Efficacy,”J. Virology78:12497-12507, 2004.
Bancroft, “Current Status of Dengue Vaccines and Prospects for the Future,”Puerto Rico Health Sci. J.6(1):23-26, 1987. Abstract only.
Bonaldo et al., “The Yellow Fever 17D Vaccine as a Vector for the Expression of Foreign Proteins: Development of New Live Flavivirus Vaccines,”Mem. Inst. Oswaldo Cruz, Rio de Janeiro95(Suppl. 1):215-223, 2000.
Bonaldo et al., “Surface Expression of an Immunodominant Malaria Protein B Cell Epitope by Yellow Fever Virus,”J. Mol. Biol.315:873-885, 2002.
Bonaldo et al., “Attenuation of Recombinant Yellow Fever 17D Viruses Expressing Foreign Protein Epitopes at the Surface,”J. Virology79:8602-8613, 2005.
Bonaldo et al., “Expression of Foreign Protein Epitopes at the Surface or Recombinant Yellow Fever 17D Viruses Based on Three-Dimensional Modeling of Its Envelope Protein,”Cell Biochem. Biophys.44:313-324, 2006.
Bray and Lai, “Construction of Intertypic Chimeric Dengue Viruses by Substitution of Structural Protein Genes,”Proc. Natl. Acad. Sci. U.S.A.88:10342-10346, 1991.
Cardosa, “Dengue Vaccine Design: Issues and Challenges,”British Med. Bull.54(2):395-405, 1998.
Carle et al., “Experiments on the Transmission of an Icterogenic Agent in Yellow Fever Vaccine to Horses and Swi

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