Chimeric flavivirus vectors

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C435S235100, C424S184100, C424S199100, C424S201100, C424S202100, C424S204100, C424S277100

Reexamination Certificate

active

07569383

ABSTRACT:
The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.

REFERENCES:
patent: 6136561 (2000-10-01), Ivy et al.
patent: 6171854 (2001-01-01), Galler et al.
patent: 6184024 (2001-02-01), Lai et al.
patent: 6416763 (2002-07-01), McDonell et al.
patent: 6682883 (2004-01-01), Monath et al.
patent: 6878372 (2005-04-01), Monath et al.
patent: 2003/0194801 (2003-10-01), Bonaldo et al.
patent: 2004/0223979 (2004-11-01), Chambers et al.
patent: 2004/0259224 (2004-12-01), Guirakhoo
patent: 2005/0002968 (2005-01-01), Monath et al.
patent: 2005/0053624 (2005-03-01), Arroyo et al.
patent: 2007/0184469 (2007-08-01), Depres et al.
patent: WO 93/06214 (1993-04-01), None
patent: WO 98/37911 (1998-09-01), None
patent: WO 01/39802 (2001-06-01), None
patent: WO 02/072835 (2002-09-01), None
patent: WO 02/102828 (2002-12-01), None
patent: WO 03/063725 (2003-08-01), None
patent: WO 03/101397 (2003-12-01), None
patent: WO 03/103571 (2003-12-01), None
patent: WO 2004/045529 (2004-06-01), None
patent: WO 2005/040390 (2005-05-01), None
patent: WO 2005/049815 (2005-06-01), None
patent: WO 2005/082020 (2005-09-01), None
patent: WO 2006/044857 (2006-04-01), None
patent: WO 2006/116182 (2006-11-01), None
patent: WO 2007/051267 (2007-05-01), None
Chambers, T, et al, 1999 Journal of Virology vol. 73 (4), 3095-3101.
Dermine et al. (Biochem Biophys Acta 2004 Vol 1704, pp. 11-35).
Arroyo et al., “Molecular Basis for Attenuation of Neurovinlence of a Yellow Fever Virus/Japanese Encephalitis Virus Chimera Vaccine (ChimeriVax-JE),” J. Virology 75(2):934-942, 2001.
Bonaldo et al., “Surface Expression of an Immunodominant Malaria Protein B Cell Epitope by Yellow Fever Virus,” J. Mol. Biol 315:873-885, 2002.
Bonaldo et al., “The Yellow Fever 17D Vaccine Virus as a Vector for the Expression of Foreign Proteins: Development of the New Live Flavivirus Vaccines,” Mem Inst Oswaldo Cruz, Rio de Janeiro 95(Suppl. 1):215-223, 2000.
De Vries et al., “Genetic Manipulation of Equine Arteritis Virus Using Full-Length cDNA Clones: Separation of Overlapping Genes and Expression of a Foreign Epitope,” Virology 270:84-97, 2000.
Li et al., “Chimeric Influenza Virus Induces Neutralizing Antibodies and Cytotoxic T Cells against Human Immunodeficiency Virus Type 1,” J. Virology 67(11):6659-6666, 1993.
McAllister et al., “Recombinant Yellow Fever Viruses are Effective Therapeutic Vaccines for Treatment of Murine Experimental Solid Tumors and Pulmonary Metastases,” J. Virology 74(19):9197-9205, 2000.
Rey et al., “The Envelope Glycoprotein from Tick-Borne Encephalitis Virus at 2 Å Resolution,” Nature 375:291-298, 1995.
Hurrelbrink et al., “Attenuation of Murray Valley Encephalitis Virus by Site-Directed Mutagenesis of the HInge and Putative Receptor-Binding Regions of the Envelope Protein,” Journal of Virology, 75:7692-7702, 2001.
Thomas J. Chambers et al., U.S. Appl. No. 09/121,587, “Chimeric Flavivirus Vaccines,” Filed: Jul. 23, 1998.
Thomas J. Chambers et al., U.S. Appl. No. 09/452,638, “Chimeric Flavivirus Vaccines,” Filed: Dec. 1, 1999.
Chambers et al., “Yellow Fever/Japanese Encephalitis Chimeric Viruses: Construction and Biological Properties,” Journal of Virology 73:3095-3101 (1999).
Goryshin et al., “In5 In Vitro Transposition,” J. Biol. Chem. 273:7387-7374 (1998).
Guirakhoo et al., “Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine,” Journal of Virology 75(16):7290-7304 (2001).
Guirakhoo et al., “Recombinant Chimeric Yellow Fever-Dengue Type 2 Virus is Immunogenic and Protective in Nonhuman Primates,” Journal of Virology 74(12):5477-5485 (2000).
Kolaskar et al, “Prediction of Three-Dimensional Structure and Mapping of Conformational Epitopes of Envelope Glycoprotein of Japanese Encephalitis Virus,” Virology 261:31-42 (1999).
Monath et al., “Chimeric Yellow Fever Virus 170-Japanese Encephalitis Virus Vaccine: Dose-Response Effectiveness and Extended Safety Testing inRhesusMonkeys,” Journal of Virology 74(4):1742-1751 (2000).
U.S. Appl. No. 08/807,445, filed Feb. 28, 1997, Chambers et al.
U.S. Appl. No. 09/007,664, filed Jan. 15, 1998, Chambers et al.
Allison et al., “Mapping of Functional Elements in the Stern-Anchor Region of Tick-Borne Encephalitis Virus Envelope Protein E,”J. Virology73:5605-5612, 1999.
Allison et al., “Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E,”J. Virology75:4268-4275, 2001.
Arroyo et al., “Yellow Fever Vector Live-Virus Vaccines: West Nile Virus Vaccine Development,”Trends Mol. Med.7:350-354, 2001.
Arroyo et al., “ChimeriVax-West Nile Virus Live-Attenuated Vaccine: Preclinical Evaluation of Safety, Immunogenicity, and Efficacy,”J. Virology78:12497-12507, 2004.
Bancroff, “Current Status of Dengue Vaccines and Prospects for the Future,”Puerto Rico Health Sci. J.6(1):23-26, 1987. Abstract only.
Barrett, “Current Status of Flavivirus Vaccines,”Ann. N. Y. Acad. Sci.951:262-271, 2001.
Bonaldo et al., “Attenuation of Recombiinant Yellow Fever 17-D Viruses Expressing Foreign Protein Epitopes at the Surface,”J. Virology79:8602-8613, 2005.
Bonaldo et al., “Expression of Foreign Protein Epitopes at the Surface or Recombinant Yellow Fever 17D Viruses Based on Three-Dimensional Modeling of Its Envelope Protein,”Cell Biochem. Biophys.44:313-324, 2006.
Bray et al., “Construction of Intertypic Chimeric Dengue Viruses by Substitution of Structural Protein Genes,”Proc. Natl. Acad. Sci. U.S.A.88:10342-10346, 1991.
Bray et al., “Genetic Determinants Responsible for Acquisition of Dengue Type 2 Virus Mouse Neurovirulence,”J. Virology72:1647-1651, 1998.
Cardosa, “Dengue Vaccine Design: Issues and Challenges,”British Med. Bull.54(2):395-405, 1998.
Carle et al., “Experiments on the Transmission of an Icterogenic Agent in Yellow Fever Vaccine to Horses and Swine,”J. Bacteriol.48:45-69, 1944.
Caufour et al., “Constuction, Characterization and Immunogenicity of Recombinant Yellow Fever 17D-Dengue Type 2 Viruses,”Virus Res.79:1-14, 2001.
Chambers et al., “Mutagenesis of the Yellow Fever Virus NS2B/3 Cleavage Site: Determinants of Cleavage Site Specificity and Effects on Polyprotein Processing and Viral Replication,”J. Virology69(3):1600-1605, 1995.
Chambers et al., “Vaccine Developement Against Dengue and Japanese Encephalitis: Report of a World Health Organization Meeting,”Vaccine15:1494-1502, 1997.
Chen et al., “Generation and Characterization of Organ-Tropism Mutants of Japaneses Encephalitis Virus In Vivo and In Vitro,”Virology223:79-88, 1996.
Cola et al., “Nucleotide and Complete Amino Acid Sequences of Kunjin Virus: Definitive Gene Order and Characteristics of the Virus-Specified Proteins,”J. Gen. Virol.69:1-21, 1988.
Davis et al., “West Nile Virus Recombinant DNA Vaccine Protects Mouse and Horse from Virus Challenge and Expressions in Vitro a Noninfectious Recombinant Antigen That Can Be Used in Enzyme-Linked Immunosorbent Assays,”J. Virology75:4040-4047, 2001.
dos Santos et al., “Complete Nucleotide Sequence of Yellow Fever Virus Vaccine Strains 17DD and 17D-213,”Virus Res.35:35-41, 1995.
dos Santos et al., “Determinants in the Envelope E Protein and Viral RNA Helicase NS3 that Influence the Induction of Apoptosis in Response to Infection with Dengue Type 1 Virus,”Virology274:292-308, 2000.
Edelman et al., “Phase I Trial of 16 Formulations of a Tetravalent Live-Attenuated Dengue Vaccine,”Am. J. Trop. Med. Hyg.69(Suppl 6):48-60, 2003.
Galler et al., “The Yellow Fever 17D Vaccine Virus: Molecu

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