Chimeric fatty body-pro-GRF analogs with increased biological po

Details Chimeric fatty body-pro-GRF analogs with increased biological po Chimeric fatty body-pro-GRF analogs with increased biological po

1996-08-23

1999-01-19

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530345, 530399, 530402, 930120, A61K 3825, C07K 1460

Patent

active

058613790

ABSTRACT:
The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

REFERENCES:
patent: 4622312 (1986-11-01), Felix et al.
patent: 4870054 (1989-09-01), Recker
patent: 5061690 (1991-10-01), Kann et al.
patent: 5065748 (1991-11-01), Bercu
patent: 5597797 (1997-01-01), Clark
Gaudreau et al., "Affinity of Human Growth Hormone-Releasing Factor (1-29)NH2 Analogues for GRF Binding Sites in Rat Adenopituitary", J. Med. Chem., vol. 35, pp. 1864-1869, 1992.
Coy et al., "Differential Effects of N-Terminal Modification on the Biological Potencies of Growth Hormone Releaseing Factor Analogues with Varying Chain Lengths", J. Med. Chem., vol. 30, pp. 219-222, 1987.
Muranishi et al, Pharmaceutical Research, vol. 8, No. 5, pp. 649-652 (1991).
Gross et al, The Peptides, vol. 3, Academic Press, pp. 1-341 (1981).
Merrifield, J. Am. Chem. Soc., 85:2149-2154 (1963).
Merrifield, J. Am. Chem. Soc., 86:304-305 (1964).
Castro et al, Tetrahedron Letters, No. 14, pp. 1219-1222 (1975).
Mergler et al, Peptides, Chemistry and Biology, Proc. of the 10th American Peptide Symp., St. Louis, pp. 259-260 (1987).
Dubreuil et al, J. Anim. Sci., vol. 68, pp. 1254-1268 (1990).
Abribat et al, Clinical Endocrinology, vol. 39, pp. 583-589 (1993).
Gaudreau et al, J. Med. Chem., vol. 35, pp. 1864-1869 (1992).
Coy et al, J. Med. Chem., vol. 30, pp. 219-222 (1987).
Gaudreau, Pierrette et al. Affinity of Human Growth Hormone-Releasing Factor (1-29)NH2 Analogues for GRF binding Sites in Rat Adenopituitary. J. Med. Chem. 1992, 35(10), 1864-1869, May 15, 1992.
Coy, D.H. et al. Differential effecst of N-terminal modifications on the biolgical potencies of growth hormone releasing factor analogues with varying chain lengths. J. Med. Chem. Oct. 1987, 30, 219-222.

Affiliated with

Also associated with

Rating

Chimeric fatty body-pro-GRF analogs with increased biological po does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric fatty body-pro-GRF analogs with increased biological po, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric fatty body-pro-GRF analogs with increased biological po will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1246708