Chimeric fatty body-pro-GRF analogs with increased biological po

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530324, 530345, 530399, 530402, 930120, A61K 3825, C07K 1460

Patent

active

058613790

ABSTRACT:
The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

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Gaudreau, Pierrette et al. Affinity of Human Growth Hormone-Releasing Factor (1-29)NH2 Analogues for GRF binding Sites in Rat Adenopituitary. J. Med. Chem. 1992, 35(10), 1864-1869, May 15, 1992.
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