Chimeric fatty body-pro-GRF (1-29) analogs with increased biolog

Details Chimeric fatty body-pro-GRF (1-29) analogs with increased biolog Chimeric fatty body-pro-GRF (1-29) analogs with increased biolog

1996-08-23

1999-08-17

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530345, 530399, 530402, 930120, A61K 3825, C07K 1460

Patent

active

059393866

ABSTRACT:
The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

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