Chimeric cytokine of IL-7 and beta-chain of HGF and methods...

Details Chimeric cytokine of IL-7 and beta-chain of HGF and methods... Chimeric cytokine of IL-7 and beta-chain of HGF and methods...

2006-11-17

2009-08-25

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C530S351000

Reexamination Certificate

active

07578998

ABSTRACT:
The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide enhances the proliferation and/or differentiation of hematopoietic precursor cells. In particular the invention relates to, a chimeric polypeptide comprising the beta-chain of hepatocyte growth factor, and IL-7 linked by at least one amino acid, and wherein the chimeric polypeptide demonstrates pre-pro-B proliferation and growth stimulating activity.

REFERENCES:
patent: 6749847 (2004-06-01), Goldschneider et al.
Mikayama et al. Proc. Natl. Acad. Sci. USAvol. 90, pp. 10056-10060.
Voet et al. Biochemistry John Wiley & Sons, Inc., pp. 126-128 and 228-234.
Laijun Lai et al., A Recombinant Single-Chain IL-7/HGF-beta Hybrid Cytokine Induces Juxtacrine Interactions of the IL-7 and HGF (c-Met) Receptors and Stimulates the Proliferation of CFU-S12, CLPs, and Pre-Pro-B Cells. Blood (2006)107(6): 1776-1784.

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