Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-12-09
1994-10-25
Hill, Jr., Robert J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 435 691, 4352402, 4352401, 4353201, 435235, 536 231, 536 235, 536 2351, 536 2352, 536 2353, 530350, 5303871, 5303873, 5303877, 5303879, 5303881, C07H 1700, A61K 3514, C12P 2100, C07K 300
Patent
active
053590465
ABSTRACT:
Chimeric proteins and DNA sequence encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA sequences may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
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Capon Daniel J.
Irving Brian A.
Roberts Margo R.
Weiss Arthur
Zsebo Krisztina
Cell Genesys Inc.
Hill Jr. Robert J.
Rowland Bertram I.
The Regents of the University of California
Wang Gian P.
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