Chimeric blood coagulation proteins

Details Chimeric blood coagulation proteins Chimeric blood coagulation proteins

1994-07-11

1996-12-24

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 696, 43525411, 4353201, 530381, 530383, 536 235, C07K 14745, C07K 14755, C12N 510, C12N 1512

Patent

active

055873103

ABSTRACT:
Chimeric blood coagulation proteins are disclosed. The proteins are (i) coagulation factor V in which at least one A3, C1 or C2 domain exon thereof is replaced with the homologous exon of coagulation factor VIII; or (ii) coagulation factor VIII in which at least one A3, C1 or C2 domain exon thereof is replaced with the homologous exon of coagulation factor V. The chimeric proteins are useful for diagnostic purposes in epitope mapping and for therapeutic purposes in facilitating blood coagulations in patients in need of such treatment.

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T. L. Ortel et al., The Journal of Biological Chemistry 267, 4189-4198 (Feb. 1992).
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