Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-12-05
2006-12-05
Kaushal, Sumesh (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S008000, C800S021000, C800S025000, C435S320100, C435S325000, C435S349000, C435S455000
Reexamination Certificate
active
07145057
ABSTRACT:
Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably integrated in the embryonic stem cells and are present in the somatic tissue of the resulting chimeras. The transgenes may encode exogenous proteins expressed in endodermal, ectodermal, mesodermal, or extra embryonic tissue. Breeding the resulting chimera yields transgenic birds whose genome is comprised of exogenous DNA.
REFERENCES:
patent: 5162215 (1992-11-01), Bosselman et al.
patent: 5340740 (1994-08-01), Petitte et al.
patent: 5656479 (1997-08-01), Petitte et al.
patent: 5830510 (1998-11-01), Petitte et al.
patent: 5897998 (1999-04-01), Speksnijder et al.
patent: 6114168 (2000-09-01), Samarut et al.
patent: 6156569 (2000-12-01), Ponce de Leon et al.
patent: 6287863 (2001-09-01), Hodgson
patent: 6333192 (2001-12-01), Petitte et al.
patent: 6515199 (2003-02-01), Petitte et al.
patent: WO 90/01541 (1990-02-01), None
patent: WO 93/23528 (1993-11-01), None
patent: WO 96/12793 (1996-05-01), None
patent: WO 00/11892 (2000-01-01), None
patent: WO 00/75300 (2000-06-01), None
patent: WO 00/47717 (2000-08-01), None
patent: WO 02/12437 (2002-02-01), None
patent: WO 03/043415 (2002-11-01), None
patent: WO 03/076601 (2003-03-01), None
van de Lavoir et al, High-grade transgenic somatic chimeras from chicken embryonic stem cells. Mech. Dev. 123(1):31-41, 2006.
“Avian transgenesis: progress towards the promise,” Ivarie, Robert, Trends in Biotechnol. vol. 21, No. 1 Jan. 2003.
“The Avian Germline and Strategies for the Production of Transgenic Chickens,” Petitte, James N., J. of Poultry Science, 39: 205-228, Jul. 2002.
“Transgenic Chickens: Past, Present and Future,” Zajchowski, L.D. et al., Poultry and Avian Biology Reviews 11(2):63-80 2000.
“Chicken Embryonic Stem Cells and Transgenic Strategies,” B. Pain et al., Cells Tissues Organs 1999; 165:212-219.
“Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple mophogenetic potentialities,” Pain, B. et al., Development 122 2339-2348, 1996).
“Transgenic chickens—methods and potential applications,” Sang, Helen, Trends in Biotechnol. 12:415-420 (1994).
“Transgenesis in Chickens,” Perry, Margaret M. et al., Transgenic Research 2, 125-133 (1993).
“Novel approaches to studies of avian endocrinology using transgenic chickens produced via chimeric intermediates,” Etches, R.J. et al., In Avian Endocrinology, Edited by P.J. Sharp, pp. 381-396, 1993 J. of Endocrinology, Bristol, UK.
Etches, R.J., “A Genetic Approach to Physiology,” Chapter 1, pp. 1-13 in “Manipulation of the Avian Genome” edited by R.J. Etches and A.M. Verrinder Gibbins (1993), CRC Press, Boca Raton.
“Production of somatic and germline chimeras in the chicken by transfer of early blastodermal cells,” Petitte, J.N. et al., Development 108, 185-189 (1990).
“Production of transgenic birds,” Shuman, R.M., Experientia 47, 897-905 (1991).
“Efficient Transfer of Chicken Blastodermal Cells and Their Incorporation Into Recipient Embryos to Produce Chimeric Chicks,” Gibbins, A.M Verrinder et al., Proceedings of the 4th World Congress on Genetics Applied to Livestock Production XVI, 119-122, Edinburgh: Jul. 23-27, 1990.
“Production of chimeric chicks by blastodermal stem cell transfer and the prospects for gene manipulation,” Etches, R.J. et al., In Avian Incubation and Embryology, Edited by S. Tullett p. 305-309 1990, 22nd British Poultry Science Symposium, British Poultry Science, Edinburgh.
“Poultry Genetics by the Year 2000,” Etches, R.J. et al., Department of Animal and Poultry Science, University of Guelph, published 1990.
Acloque, Hervc et al., “Identification of a new gene family specifically expressed in chicken embryonic stem cells and early embryo,” Mechanisms of Development 103 (2001) 79-91.
Acloque Herve et al., “Indentification of a new gene family specifically expressed in chicken embryonic stem cells and early embryo,” Mechanisms of Development 103 (2001) 79-91.
Beemer Kathleen
Diamond Jennifer
Etches Robert J.
Heyer Babette
Mather Christine
Kaushal Sumesh
Origen Therapeutics, Inc.
Orrick Herrington & Sutcliffe LLP
LandOfFree
Chimeric bird from embryonic stem cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric bird from embryonic stem cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric bird from embryonic stem cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3687970