Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-12-25
2007-12-25
Schultz, J. Douglas (Department: 1639)
Chemistry: molecular biology and microbiology
Vector, per se
C435S006120, C435S007100
Reexamination Certificate
active
09486882
ABSTRACT:
There is described a method of isolating nucleotide sequences encoding target peptides from DNA libraries using DNA binding proteins to link the peptide to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest, or from synthetic DNA, and inserted into, or adjacent to, a DNA binding protein in an expression vector to create a chimeric fusion protein. Incorporation of the vector DNA into a carrier package, during expression of the chimeric fusion protein, results in the production of a peptide display carrier package (PDCP) displaying the DNA-bound fusion protein on the external surface of the carrier package. Employment of affinity purification techniques results in the PDCP particles containing sequences encoding the desired peptide to be selected and the desired nucleotide sequences obtained therefrom.
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Gross Christopher M.
Quinn Charles N.
Schultz J. Douglas
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