Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1996-08-23
1999-09-28
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
4353201, 435325, 435366, 435455, 536 245, C07H 2104, C12N 516, C12N 522, C12N 1579, C12N 1585
Patent
active
059587687
ABSTRACT:
Methods and compositions for the treatment and diagnosis of infections of Rev-binding primate lentiviruses are provided. These methods and compositions utilize the ability of Rev binding nucleic acids such as the SLII sequence from the HIV-1 Rev response element (RRE) to target therapeutic agents to the same sub-cellular location as primate lentiviruses which contain RRE sequences. In particular, the invention provides trans-acting ribozymes comprising Rev-binding nucleic acids less toxic than a full-length RRE, and molecules encoding them. The use of the compositions of the invention as components of diagnostic assays, as prophylactic reagents, and in vectors is also described.
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Kraus Gunter
Wong-Staal Flossie
Yamada Osamu
Yu Mang
Nelson Amy J.
Smith Lynette F.
The Regents of the University of California
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