Chimeric antibody with specificity to human B cell surface antig

Details Chimeric antibody with specificity to human B cell surface antig Chimeric antibody with specificity to human B cell surface antig

1991-03-05

1996-03-19

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241331, 4241531, 4241551, 435 724, 435 7021, 4351722, 43524027, 5303873, 53038873, A61K 39395, C07K 1630, G01N 33574

Patent

active

055003621

ABSTRACT:
The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention also relates to the increased ADCC and CDC cytolytic activities of the chimeric antibody, methods of production by recombinant DNA techniques, and uses.

REFERENCES:
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4486538 (1984-12-01), Bogoch
patent: 4650756 (1987-03-01), Old et al.
patent: 4708862 (1987-11-01), Baldwin
patent: 4816567 (1989-03-01), Cabilly et al.
Clark et al, Proc. Natl. Acad. Sci. USA, 82, 1776-1770, 1985.
Marx, Science, 229, 455-456, 1985.
Stashenko et al, Journ. Immunol., 125, 1678-1685, 1980.
Hellstrom et al, in Baldwin et al (Eds.), Monollonal Antibodies for Cancer Detection and Therapy, Academic Press, New York, 1985, pp. 34-36.
Nadler et al, Journ. Clin. Invest, 67, 134-140, 1981.
Nose et al, Proc. Natl Acad. Sci. USA, 80, 6632-6636, 1983.
I. M. Roitt, Essential Immunology, Blackwell Scientific Publications, Oxford, UK, 1984, p. 165.
Steplewski et al., Proc. Natl. Acad. Sci. USA 85:4852-4856 (1988).
Bruggemann et al., J. Exp. Med. 166:1351-1361 (1987).
Liu, et al., Proc. Natl. Acad. Sci. USA 84:3439-3443 (1987).
Liu, et al., J. Immunol. 139:3521-3526 (1987).
Sun et al., Proc. Natl. Acad. Sci. USA 84:214-218 (Jan. 1987).
Nishimura et al., Canc. Res. 47:999-1005 (1987).
Sahagan et al., J. Immun., 137:1066-1074 (Aug. 1986).
Brown et al., Canc. Res., 47:3577-3583 (1987).
Sun, L. K., et al., Hybridoma, 5, suppl. 1 S17-S19 (1986).
Morrison, S. L. et al., Proc. Natl. Acad. Sci., USA, 81: 6851-6855 (Nov. 1984).
Boulianne, G. L. et al., Nature, 312:643-646 (Dec. 13, 1984).
Neuberger, M. S. et al., Nature, 314:268-270 (Mar. 25, 1985).
Neuberger, M. S. et al., Nature, 312:604-609 (1984).
Williams, G. et al., Gene, 43:319-324 (1986).
Takeda, S. et al., Nature, 314:452-454 (Apr. 4, 1985).
Cabilly, S. et al., Proc. Natl. Acad. Sci., USA, 81:3273-3277 (Jun. 1984).
Wood, C. R. et al., Nature, 314:446-449 (Apr. 1985).
Tan, et al., J. Immunol., 135:3564-3567 (Nov. 1985).
Jones, P. T., et al., Nature, 321:522-525 (May 1986).
Morrison, S. L., Science, 229:1202-1207 (Sep. 20, 1985).
Oi, V. T., et al., BioTechniques, 4:214-221 (1986).
European Search Report for related EPO Application No. EP/87115769.
International Search Report for related PCT Application No. 88/03145.

Affiliated with

Also associated with

Rating

Chimeric antibody with specificity to human B cell surface antig does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric antibody with specificity to human B cell surface antig, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric antibody with specificity to human B cell surface antig will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1959000