Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1995-06-06
1997-10-14
Saunders, David
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435 696, 435 7021, 4351723, 4353431, 4352542, C12N 119, C12N 520, C12N 1513
Patent
active
056771800
ABSTRACT:
The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of producing the antibody.
REFERENCES:
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4486538 (1984-12-01), Bogoch
patent: 4650756 (1987-03-01), Old et al.
patent: 4708862 (1987-11-01), Baldwin
patent: 4724212 (1988-02-01), Epstein
patent: 4724213 (1988-02-01), Epstein
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5500362 (1996-03-01), Robinson et al.
Boulianne, G.L. et al., "Production of Functional Chimaeric Mouse/Human Antibody," Nature 312:643-646, Dec. 1984.
Brown, B.A. et al., "Tumor-Specific Genetically Engineered Murine/Human Chimeric Monoclonal Antibody," Cancer Research 47:3577-3583, Jul. 1987.
Bruggemann, M. et al., "Comparison of the Effector Functions of Human Immunoglobulins Using a Matched Set of Chimeric Antibodies," J. Exp. Med. 166:1351-1361, Nov. 1987.
Cabilly, S. et al., "Generation of Antibody Activity from lmmunoglobulin Polypeptide Chains Produced in Escherichia coli," Proc. Natl. Acad. Sci., USA 81:3273-3277, Jun. 1984.
European Search Report for EPO Application No. EP.87115769.9.
Hellstrom et al. in Baldwin et al., "Monoclonal Antibodies for Cancer Detection and Therapy," Academic Press, New York, pp. 34-36, Jan. 1985.
International Search Report for PCT Application No. 88/03145.
Jones, P.T. et al., "Replacing the Complementarity-Determining Regions in a Human Antibody with Those From a Mouse," Nature 321:522-525, May 1986.
Liu, A.Y. et al., "Chimeric Mouse-Human IgG1 Antibody That Can Mediate Lysis of Cancer Cells," Proc. Natl. Acad. Sci., USA 84:3439-3443, May 1987.
Liu, A.Y. et al., "Production of a Mouse-Human Chimeric Monoclonal Antibody to CD20 with Potent Fc-Dependent Biologic Activity," J. Immunol. 139:3521-3526, Nov. 1987.
Marx, J.L., "Antibodies Made to Order," Science 229:455-456, Aug. 1985.
Morrison, S.L. et al., "Chimeric Human Antibody Molecules: Mouse Antigen-Binding Domains with Human Constant Region Domains," Proc. Natl. Acad. Sci., USA 81:6851-6855, Nov. 1984.
Morrison, S.L., "Transfectomas Provide Novel Chimeric Antibodies," Science 229:1202-1207, Sep. 1985.
Nadler, L.M. et al., "A Unique Cell Surface Antigen Identifying Lymphoid Malignancies of B Cell Origin," J. Clin. Invest. 67:134-140, Jan. 1981.
Neuberger, M.S. et al., "A Hapten-Specific Chimaeric IgE Antibody with Human Physiological Effector Function," Nature 314:268-270, Mar. 1985.
Neuberger, M.S. et al., "Recombinant Antibodies Possessing Novel Effector Functions," Nature 312:604-409, Dec. 1984.
Nishimura, Y. et al., "Recombinant Human-Mouse Chimeric Monoclonal Antibody Specific for Common Acute Lymphocytic Leukemia Antigen," Canc. Res. 47:999-1005, Feb. 1987.
Nose, M. et al, "Biological Significance of Carbohydrate Chains on Monoclonal Antibodies," Proc. Natl. Acad. Sci., USA 80:6632-6636, Nov. 1983.
Oi, V.T., et al., "Chimeric Antibodies," Biotechniques 4:214-221, May/Jun. 1986.
Roitt, I.M., "Essential Immunology," Blackwell Scientific Publications, Oxford, U.K., p. 165, 1984.
Sahagan, B.G. et al., "A Genetically Engineered Murine/Human Chimeric Antibody Retains Specificity for Human Tumor-Associated Antigen," J. lmmunol. 137: 1066-1074, Aug. 1986.
Steplewski, Z. et al., "Biological Activity of Human-Mouse IgG1, IgG2, lgG3, and IgG4 Chimeric Monoclonal Antibodies with Antitumor Specificity," Proc. Natl. Acad. Sci., USA 85:4852-4856, Jul. 1988.
Sun, L.K. et al., "Chimeric Antibody with Human Constant Regions and Mouse Variable Regions Directed Against Carcinoma-Associated Antigen 17-1A," Proc. Natl. Acad. Sci., USA 84:214-218, Jan. 1987.
Sun, L.K. et al, "Chimeric Antibodies with 17-1A-Derived Variable and Human Constant Regions," Hybridoma 5(Supp1):17-19, Jul. 1986.
Takeda, S. et al., "Construction of Chimaeric Processed Immunoglobulin Genes Containing Mouse Variable and Human Constant Region Sequences," Nature 314:452-454, Apr. 1985.
Tan, L.K. et al., "A Human-Mouse Chimeric Immunoglobulin Gene with a Human Variable Region is Expressed in Mouse Myeloma Cells," J. Immunol. 135:3564-3567, Nov. 1985.
Williams, G.T. et al., "Production of antibody-tagged Enzymes by Myeloma Cells: Application to DNA Polymerase I Klenow," Gene 43:319-324, Aug. 1986.
Wood, C.R. et al., "The Synthesis and in vivo Assembly of Functional Antibodies in Yeast," Nature 314:446-449, Apr. 1985.
Clark et al, Proc. Natl. Acad. Sci. USA, 82, 1766-1770, 1985.
Stashenko et al, Journ. Immunol; 125, 1678-1685, 1980.
Ledbetter Jeffrey A.
Liu Alvin Y.
Robinson Randy R.
Saunders David
Xoma Corporation
LandOfFree
Chimeric antibody with specificity to human B cell surface antig does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric antibody with specificity to human B cell surface antig, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric antibody with specificity to human B cell surface antig will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1554466