Chimeric antibody for detection and therapy of infectious and in

Details Chimeric antibody for detection and therapy of infectious and in Chimeric antibody for detection and therapy of infectious and in

1995-06-01

1997-06-10

Feisee, Lila

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 111, 424 93, 4241531, 4241821, 4241781, A61K 39395

Patent

active

056372884

ABSTRACT:
A chimeric antibody-agent conjugate for targeting foci of leukocyte accretion comprises a recombinant chimera having an antigen-binding hypervariable region which binds specifically to granulocytes, and a constant region of a human immunoglobulin having an Fc portion with high affinity for receptors on human mononuclear lymphoid cells, said chimera being conjugated to at least one diagnostic agent or therapeutic agent.
A method for targeting an imaging or therapy agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above chimeric anti-leukocyte conjugate.

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Harris et al., TibTech, 11:42, 1993.
Abramowicz et al., The New England Journal of Medicine, 736, 1992.
Morrison et al. Clin Chem 34/9 1668-1675 (1988).

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