Chimeric antibodies directed against a human glycoprotein antige

Details Chimeric antibodies directed against a human glycoprotein antige Chimeric antibodies directed against a human glycoprotein antige

1989-07-31

1996-12-03

Feisee, Lila

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, 435 696, 536 2353, C12N 506, C12N 1513, C12N 1585

Patent

active

055807747

ABSTRACT:
The present invention discloses novel chimeric monoclonal antibodies, directed against proteoglycans of human melanoma cells, having antigen-specific variable regions of defined amino acid sequences. DNA constructs for the light and heavy chain variable regions comprising the novel antibodies of the invention are provided. Eukaryotic host cells capable of expression of the chimeric antibodies and comprising the novel chimeric antibody-encoding DNA constructs are also provided.

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