Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-12-22
1999-10-19
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303881, 5303882, 53038873, 53038875, C07K 1600, C12P 2108
Patent
active
059691093
ABSTRACT:
The present invention relates to chimeric antibodies which comprise a B cell epitope, a T cell epitope, and/or an antigen binding site. The chimeric antibodies may be produced by replacing at least a portion of an immunoglobulin molecule with the desired epitope or antigen binding site such that the functional capabilities of the epitope and the parent immunoglobulin are retained. The chimeric antibodies of the invention may be used to enhance an immune response against pathogens and tumor cells in subjects in need of such treatment.
REFERENCES:
patent: Re32833 (1989-01-01), Greene et al.
patent: 5231167 (1993-07-01), Zanetti et al.
patent: 5508386 (1996-04-01), Zanetti et al.
The Journal of Immunology, Brumeanu et al., 1995, 154:3088-3095.
Journal of Chromatography A, Brumeanu et al., 1995, 696:219-225.
Proc. Natl., Acad. Sci. USA, Zaghouani et al., 1995, 92:631-635.
Inter. Rev. Immunol., Shin et al., 1993, 10:177-186.
Il Farmaco, Schiavon et al., 1990, 45 (Supplemental to N.6):791-795.
Nature, Clarke et al., 1987, 330:381-384.
Riechmann et al Nature VOI 332:323-327, 1988.
Bodmer et al Cell vol. 52:253-258, 1988.
Rotschke et al Eur J Immunology vol. 21:2891-2894, 1991.
Herbert et al (The Dictionary of Immunology, Academic Press,) London, p. 78, 1995.
Webster's New Riverside University Dictionary, The Riverside Publishing Co., Boston, p. 1156, 1994.
Rossiter et al., 1994, Eur. J. Immunol. 24:1244-1247.
Zaghouani et al., 1994, FASEB J. 6:A962, abstract 5570.
Billetta and Zanetti, 1993, Inter. Rev. Immunol. 10:25.
Biotechnology News, Jan. 22, 1993.
Leff, BioWorld Today, Jan. 12, 1993.
Kuzu et al., 1993, International Immunol. 5:1301-1307.
Selisko et al., 1993, J. Chromatogr. 641:71-79.
Zaghouani et al., 1993, Abstract presented at Conference on Advances in AIDS Vaccine Development, Alexandria, VA Oct. 30--Nov. 4, 1993.
Zaghouani et al., 1993, Eur. J. Immunol. 23:2746-2750.
Zaghouani et al., 1993, International Review Immunol. 10:265-278.
Zaghouani et al., 1993, Science 259:224-227.
Zanetti et al., 1993, EMBO J. 12:4375-4384.
Billetta, 1992, FASEB J. 6:A2012, abstract 6226.
Cunningham-Rundles et al., 1992, J. Immunol. Methods 152:177-190.
Kuzu et al., 1992, FASEB J. 6:A1968, abstract 5977.
Lanza et al., 1992 FASEB J. 6:A4100, abstract 2690.
Li et al., 1992, J. Virol. 66:399-404.
Nelson et al., 1992, Proc. Natl. Acad. Sci. U.S.A. 89:7380-7383.
Partidos et al., 1992, Eur. J. Immunol 22:2675-2680.
Rossi et al., 1992, FASEB J. 6:A1400, abstract 2691.
Snider et al., 1992, J. Chromatogr. 599:141-155.
Warren et al., 1992, J. Clin. Microbiol. 30:126-131.
Warren et al., 1992, J. Virol. 66:5210-5215.
Zaghouani et al., 1992, J. Immunol. 148:3604-3609.
Zanetti et al., 1992, Immunological Reviews 1992, No. 130, pp. 125-150.
Zanetti, 1992, Nature 355:476-477.
Billetta et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88:4713-4717.
Kitamura et al., 1991, Cancer Res. 51:4310-4315.
Klibanov et al., 1991, Biochim. Biophys. Acta 1062-142.
Leclerc, 1991, J. Immunol. 147:3545-3552.
Moran et al., 1991, Journal of Immunology 146:321-326.
Neville et al., 1991, presented at the American Association of Pharmaceutical Scientists', Sixth Annual Meeting, Washington, DC Nov. 17-21.
Rotzschke et al., 1991, Immunol. Today 12:447-455.
Waldmann, 1991, Science 252:1657.
Zaghouani et al., 1991, FASEB J. 5:A1334, abstract 5587.
Zaghouani et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88:5645-5649.
Billetta, 1990, FASEB J. 4:A1763, abstract 402.
Durda et al., 1990, Aids Research and Human Retroviruses 6:1115-1123.
Goron et al., 1990, Journal of Immunology 129:199-205.
Ho et al., 1990, Eur. J. Immunol. 20:477-483.
Kitamura et al., 1990, Biochem. Biophys. Res. Commun.:1387.
Moran et al., 1990, J. Immuno. Methods 129:199-205.
Sollazzo et al, 1990, Protein Engineering 4:215-220.
Sollazzo et al., 1990, in The Year In Immunology 1989-1990, Cruse et al., eds., vol. 6, Basel Karger, pp. 162-184.
Sollazzo et al., 1990, Protein Engineering 3:531-539.
Carlsson et al., 1989, Bio/Technology 7:567-573.
Liou et al., 1989, J. Immuno. 143:3967-3975.
Sollazzo et al., 1989, Cur. J. Immunol. 19:453-457.
Webb et al., 1989, Proc. Natl. Acad. Sci. USA, 86:7731-7735.
Dangl et al., 1988, EMBO. J. 7:1989-1994.
Morrison et al., 1988, Clin. Chem. 34(9):1668-1675.
Rathburn et al., 1988, J. Mol. Biol. 202:383-395.
Ito et al., 1987, J. Immunol. Met. 103:229.
Jackson et al., 1987, Anal-Biochem. 165:114-127.
Lewin, 1987, "Genes III", John Wiley and Sons, N.Y. pp. 642-649.
Moran et al., 1987, Vir. Immunol. 1:1-12.
Sanz et al., 1987, Proc. Natl. Acad. Sci. USA 84:1085-1089.
Wilkinson et al., 1987, Immunol. Lett. 15:17-22.
Wong et al., 1987, Journal of Immunology 139:1369-1374.
Zanetti et al., 1987, Immunology Today 8:18-25.
Jones et al., 1986, Nature 321:522-525.
Morrison et al., 1986, Mount Sinai J. Med. 53:175-180.
Oi et al., 1986, Bio Techniques 4:214-221.
Perez et al., 1985, Letters to Nature 316:354-356.
Mosmann, 1983, J. Immunol. Methods 65:55.
Swain et al., 1983, J. Exp. Med. 158:822-835.
Bona Constantin
Zaghouani Habib
Hutzell Paula K.
Kole Lisa B.
Ungar Susan
LandOfFree
Chimeric antibodies comprising antigen binding sites and B and T does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric antibodies comprising antigen binding sites and B and T, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric antibodies comprising antigen binding sites and B and T will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2056913