Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-05
1998-12-01
Ziska, Suzanne E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
5303882, 5303888, 53038885, 5303897, 5303881, 4351723, 435 696, 536 231, 536 2353, C12N 1500, C12P 2106, C12P 2104, C07K 1600
Patent
active
058437088
ABSTRACT:
The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, for localization and in vivo imaging of tumors, for therapy, e.g. site-directed delivery of cytotoxins, and similar purposes. The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or derivatives thereof.
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de Winter Ronald F.J.
Gill Laura Lee
Hardman Norman
Heusser Christoph
Wagner Kathrin
Ciba-Geigy Corporation
Nowak Henry P.
Ziska Suzanne E.
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