Chemistry: molecular biology and microbiology – Vector – per se
Patent
1996-11-20
1999-03-02
Guzo, David
Chemistry: molecular biology and microbiology
Vector, per se
536 2372, C12N 1586
Patent
active
058770119
ABSTRACT:
A chimeric adenoviral vector is provided that comprises nucleotide sequence of a first adenovirus, wherein at least one gene of said first adenovirus encoding a protein that facilitates binding of said vector to a target mammalian cell, or internalization thereof within said cell, is replaced by the corresponding gene from a second adenovirus belonging to subgroup D, said vector further comprising a transgene operably linked to a eucaryotic promoter to allow for expression therefrom in a mammalian cell. Additionally, a method of delivering transgenes to target mammalian cells, particularly airway epithelial cells, is provided.
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Armentano Donna
Gregory Richard J.
Smith Alan E.
Genzyme Corporation
Guzo David
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