Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-03-13
2000-10-03
Guzo, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 691, 435 697, 4352351, 4353201, 435440, 530300, 530350, 536 242, C07K 1600, C07H 2104, C12P 2102, C12N 1563
Patent
active
061275255
ABSTRACT:
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against the corresponding wild-type adenovirus coat protein. The invention also provides an adenovirus comprising a chimeric adenovirus coat protein, and methods of constructing and using such an adenovirus, for instance, in gene therapy.
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Crystal Ronald G.
Falck-Pedersen Erik
Gall Jason
Kovesdi Imre
Wickham Thomas J.
Cornell Research Foundation Inc.
GenVec, Inc.
Guzo David
Shuman Jon
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