Chimeral polypeptide composition for cross-placenta delivery

Details Chimeral polypeptide composition for cross-placenta delivery Chimeral polypeptide composition for cross-placenta delivery

2011-01-18

2011-01-18

Szperka, Michael (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S134100, C424S192100

Reexamination Certificate

active

07871624

ABSTRACT:
The invention is directed to chimeral fusion proteins having an IgG1 antibody Fc portion and a lysosomal storage enzyme, particularly a Fc-GUS fusion protein useful in treating Sly's disease in an embryo or fetus. The invention is also directed to methods of treating in born errors of metabolism, particularly Sly's disease, in a fetus by delivering to a pregnant mother a Fc-MPS emzyme fusion protein.

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