Chimaeric plant viruses with mucin peptides

Details Chimaeric plant viruses with mucin peptides Chimaeric plant viruses with mucin peptides

2005-12-27

2005-12-27

Mehta, Ashwin (Department: 1638)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

C424S093200, C424S204100, C424S205100

Reexamination Certificate

active

06979448

ABSTRACT:
Mucin peptide epitopes are inserted into the coat protein of a plant virus (e.g., a comovirus such as CPMV) having a beta-barrel structure at an immunogenically effective site, such as in a loop connecting beta sheets or at
ear the C-terminus. The resulting chimaeric virus particles are extremely immunogenic, giving better results than KLH conjugation and not requiring the addition of exogenous adjuvant. They are effective at mucosal surfaces, particularly when administered intranasally.

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