Chimaeric phages

Details Chimaeric phages Chimaeric phages

2011-03-08

2011-03-08

Leavitt, Maria (Department: 1633)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S005000, C435S006120, C435S069100, C435S069700, C536S023400

Reexamination Certificate

active

07901919

ABSTRACT:
The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages.

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