Chicken anemia virus mutants and vaccines and uses based on the

Details Chicken anemia virus mutants and vaccines and uses based on the Chicken anemia virus mutants and vaccines and uses based on the

1997-08-14

1999-09-14

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4353201, 4352523, 435325, 435348, 4352351, 514 44, 4242041, 4242051, 4241861, 4241921, 536 2372, 530350, A61K 3912, A61K 9127, C12N 700, C12N 1534

Patent

active

059520027

ABSTRACT:
Novel proteins of the Chicken Anemia Virus are described and compositions for preventing or treating infections with that virus (CAV), in particular vaccines less pathogenic than the CAV itself, but yet leading to neutralizing antibodies in the immunized animal. Besides, there are described compositions containing antibodies against parts of the CAV for the control of infections with CAV and anti-idiotype antibodies. The invention also provides antibodies and test kits for the detection of CAV. Recombinant DNA molecules derived from CAV and host cells transfected therewith and vaccines based on these host cells are made possible by this invention. The invention also comprises living virus vaccines in which a piece of DNA is brought into a virus infectious to the host. Besides, the invention provides uses of proteins of CAV in the induction of apoptosis, in particular in tumor cells. It further provides the induction of cell death by means of gene therapy.

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