Chewing gum with dental health benefits employing calcium glycer

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical

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424 48, 424682, 426 3, A61K 968, A61K 3306

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active

053781317

ABSTRACT:
A method and composition for preventing, or reducing the risk of, dental caries. Pursuant to the present invention, a chewing gum is provided that includes a therapeutically effective amount of calcium glycerophosphate. The chewing gum, by including a therapeutically effective amount of calcium glycerophosphate, not only eliminates any cariogenic effects of the chewing gum itself, but actually improves dental health when chewed before or after a meal containing fermentable carbohydrates.

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patent: 4867989 (1989-09-01), Silva et al.
patent: 4906455 (1990-03-01), Hoerman
Featherstone, "An Updated Understanding of the Mechanism of Dental Decay and its Prevention", Nutrition Quarterly, vol. 14, No. 1, 1990, pp. 5-11.
Regolati et al., "Cariostatic Effect of Glycerophosphate", Helv. Odont. Acta, vol. 16, Apr. 1972, pp. 13-18.
Bowen, "The Cariostatic Effect of Calcium Glycerophosphate in Monkeys", Caries Res. 6, pp. 43-51.
Brook, "Calcium Glycerophosphate and Dental Plaque", Caries Res. 9, pp. 156-162 (1975).
Grenby et al., "Protection Against Dental Caries in Rats by Glycerophosphates or Calcium Salts or Mixtures of Both", Archs Oral Biol., vol. 20, No. 11, Nov. 1975, pp. 717-724.
Pianotti et al., "Cariostatic Activity of Calcium Glycerophosphate in Hamsters: Topical vs Dietary Administration", J Dent Res, vol. 55, No. 6, Nov.-Dec. 1976, pp. 1092-1096.

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