Drug – bio-affecting and body treating compositions – Chewing gum type
Patent
1997-07-07
1999-09-28
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Chewing gum type
424 49, 424 57, 424440, 426 3, A61K 968, A61K 716
Patent
active
059583800
ABSTRACT:
This invention relates to a stable, single-part chewing gum product and methods of using same to effect remineralization of subsurface lesions in teeth and/or mineralization of exposed dentinal tubules. The chewing gum product contains a water-soluble cationic portion, a water-soluble anionic portion and a stabilizing component which substantially inhibits reaction between the cationic and anionic portions during storage of the chewing gum product but which allows the cationic and anionic portions to be simultaneously released at a substantially equal rate from the product when the product is chewed in the presence of saliva and/or water. The cationic portion is composed of at least one water-soluble calcium salt, and the anionic portion contains at least one water-soluble phosphate and, optionally, at least one water-soluble fluoride salt. The stabilizing component may be at least one water-soluble divalent metal salt other than calcium salt, the divalent metal salt being disposed in the cationic portion of the product. Alternatively, the stabilizing component may be a desiccating agent or an encapsulating coating, wherein the encapsulating coating is disposed on particles of one or both of the cationic and anionic portions.
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Usen Norman
Winston Anthony E.
Enamelon Inc.
Rose Shep K.
LandOfFree
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